node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CobI_1 | CysG_1 | RMCT_4352 | RMCT_2617 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | uroporphyrin-III C-methyltransferase hemD. | 0.988 |
CobI_1 | CysG_2 | RMCT_4352 | RMCT_4281 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | 0.995 |
CobI_1 | HemB | RMCT_4352 | RMCT_2616 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.495 |
CobI_1 | HemC | RMCT_4352 | RMCT_2618 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.519 |
CobI_1 | RMCT_4397 | RMCT_4352 | RMCT_4397 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | Possible transcriptional regulatory protein. | 0.460 |
CobI_1 | hemA | RMCT_4352 | RMCT_2620 | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.547 |
CysG_1 | CobI_1 | RMCT_2617 | RMCT_4352 | uroporphyrin-III C-methyltransferase hemD. | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | 0.988 |
CysG_1 | CysG_2 | RMCT_2617 | RMCT_4281 | uroporphyrin-III C-methyltransferase hemD. | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | 0.995 |
CysG_1 | HemB | RMCT_2617 | RMCT_2616 | uroporphyrin-III C-methyltransferase hemD. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.999 |
CysG_1 | HemC | RMCT_2617 | RMCT_2618 | uroporphyrin-III C-methyltransferase hemD. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
CysG_1 | RMCT_2612 | RMCT_2617 | RMCT_2612 | uroporphyrin-III C-methyltransferase hemD. | Transmembrane protein. | 0.951 |
CysG_1 | RMCT_2613 | RMCT_2617 | RMCT_2613 | uroporphyrin-III C-methyltransferase hemD. | Transmembrane protein. | 0.955 |
CysG_1 | RMCT_4397 | RMCT_2617 | RMCT_4397 | uroporphyrin-III C-methyltransferase hemD. | Possible transcriptional regulatory protein. | 0.953 |
CysG_1 | cysC | RMCT_2617 | RMCT_1372 | uroporphyrin-III C-methyltransferase hemD. | Bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.965 |
CysG_1 | hemA | RMCT_2617 | RMCT_2620 | uroporphyrin-III C-methyltransferase hemD. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.980 |
CysG_1 | hemE | RMCT_2617 | RMCT_0671 | uroporphyrin-III C-methyltransferase hemD. | Uroporphyrinogen decarboxylase hemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.956 |
CysG_2 | CobI_1 | RMCT_4281 | RMCT_4352 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family. | 0.995 |
CysG_2 | CysG_1 | RMCT_4281 | RMCT_2617 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | uroporphyrin-III C-methyltransferase hemD. | 0.995 |
CysG_2 | HemB | RMCT_4281 | RMCT_2616 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.921 |
CysG_2 | HemC | RMCT_4281 | RMCT_2618 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |