| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MoeZ | RibD_1 | RMCT_2348 | RMCT_3645 | Molybdopterin biosynthesis-like protein MoeZ. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.541 |
| MoeZ | TenA | RMCT_2348 | RMCT_0256 | Molybdopterin biosynthesis-like protein MoeZ. | Transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | 0.595 |
| MoeZ | ThiD | RMCT_2348 | RMCT_2715 | Molybdopterin biosynthesis-like protein MoeZ. | Phosphomethylpyrimidine kinase. | 0.878 |
| MoeZ | ThiS | RMCT_2348 | RMCT_2729 | Molybdopterin biosynthesis-like protein MoeZ. | Thiamine biosynthesis protein ThiS. | 0.942 |
| MoeZ | guaA | RMCT_2348 | RMCT_0588 | Molybdopterin biosynthesis-like protein MoeZ. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.822 |
| MoeZ | thiC | RMCT_2348 | RMCT_2714 | Molybdopterin biosynthesis-like protein MoeZ. | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.861 |
| MoeZ | thiE | RMCT_2348 | RMCT_2731 | Molybdopterin biosynthesis-like protein MoeZ. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.892 |
| MoeZ | thiG | RMCT_2348 | RMCT_2728 | Molybdopterin biosynthesis-like protein MoeZ. | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.978 |
| MoeZ | thiL | RMCT_2348 | RMCT_3523 | Molybdopterin biosynthesis-like protein MoeZ. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.478 |
| RMCT_2720 | ThiD | RMCT_2720 | RMCT_2715 | Alpha/beta hydrolase superfamily enzyme, predicted hydrolase. | Phosphomethylpyrimidine kinase. | 0.802 |
| RMCT_2720 | thiC | RMCT_2720 | RMCT_2714 | Alpha/beta hydrolase superfamily enzyme, predicted hydrolase. | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.443 |
| RibD_1 | MoeZ | RMCT_3645 | RMCT_2348 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Molybdopterin biosynthesis-like protein MoeZ. | 0.541 |
| RibD_1 | ThiD | RMCT_3645 | RMCT_2715 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphomethylpyrimidine kinase. | 0.692 |
| RibD_1 | guaA | RMCT_3645 | RMCT_0588 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.729 |
| RibD_1 | thiC | RMCT_3645 | RMCT_2714 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.551 |
| RibD_1 | thiE | RMCT_3645 | RMCT_2731 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.553 |
| RibD_1 | thiL | RMCT_3645 | RMCT_3523 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.767 |
| TenA | MoeZ | RMCT_0256 | RMCT_2348 | Transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | Molybdopterin biosynthesis-like protein MoeZ. | 0.595 |
| TenA | ThiD | RMCT_0256 | RMCT_2715 | Transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | Phosphomethylpyrimidine kinase. | 0.999 |
| TenA | ThiS | RMCT_0256 | RMCT_2729 | Transcriptional activator; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. | Thiamine biosynthesis protein ThiS. | 0.702 |