Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PrpD2-methylcitrate dehydratase. (507 aa)    
Predicted Functional Partners:
AcnA
Aconitate hydratase.
  
 
 0.938
GltA2
Type II citrate synthase; Belongs to the citrate synthase family.
  
  
 0.915
PrpB
PEP phosphonomutase-like enzyme.
 
  
 0.861
RMCT_2657
Transcriptional regulator.
 
  
 0.844
CitA
Citrate synthase 2; Belongs to the citrate synthase family.
  
  
 0.759
CitE
Citrate lyase beta subunit citE; Belongs to the HpcH/HpaI aldolase family.
 
  
 0.584
RMCT_2966
Putative uncharacterized protein.
       0.565
RMCT_0924
acetyl-/propionyl-CoA carboxylase beta subunit accD1.
  
  
 0.496
AcsA_3
acyl-CoA synthetase/AMP-acid ligase.
  
  
 0.492
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
  
 0.483
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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