| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BtuR | CobN | RMCT_4279 | RMCT_4355 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobalamin biosynthesis protein cobN. | 0.992 |
| BtuR | CobU_1 | RMCT_4279 | RMCT_2679 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Bifunctional cobalamin biosynthesis protein CobU. | 0.980 |
| BtuR | CobU_2 | RMCT_4279 | RMCT_3860 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Adenosyl cobinamide kinase. | 0.982 |
| BtuR | MetH | RMCT_4279 | RMCT_3940 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.629 |
| BtuR | RMCT_3127 | RMCT_4279 | RMCT_3127 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.962 |
| BtuR | cobB-3 | RMCT_4279 | RMCT_4280 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.991 |
| BtuR | cobD | RMCT_4279 | RMCT_3824 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.982 |
| BtuR | cobQ | RMCT_4279 | RMCT_4268 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.982 |
| BtuR | cobS | RMCT_4279 | RMCT_3858 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobalamin 5-phosphate synthase cobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.988 |
| CobN | BtuR | RMCT_4355 | RMCT_4279 | Cobalamin biosynthesis protein cobN. | cob(I)yrinic acid a,c-diamide adenosyltransferase. | 0.992 |
| CobN | CobU_1 | RMCT_4355 | RMCT_2679 | Cobalamin biosynthesis protein cobN. | Bifunctional cobalamin biosynthesis protein CobU. | 0.606 |
| CobN | CobU_2 | RMCT_4355 | RMCT_3860 | Cobalamin biosynthesis protein cobN. | Adenosyl cobinamide kinase. | 0.618 |
| CobN | MetH | RMCT_4355 | RMCT_3940 | Cobalamin biosynthesis protein cobN. | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.597 |
| CobN | RMCT_3127 | RMCT_4355 | RMCT_3127 | Cobalamin biosynthesis protein cobN. | ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.944 |
| CobN | cobB-3 | RMCT_4355 | RMCT_4280 | Cobalamin biosynthesis protein cobN. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.981 |
| CobN | cobD | RMCT_4355 | RMCT_3824 | Cobalamin biosynthesis protein cobN. | Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.724 |
| CobN | cobQ | RMCT_4355 | RMCT_4268 | Cobalamin biosynthesis protein cobN. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.695 |
| CobN | cobS | RMCT_4355 | RMCT_3858 | Cobalamin biosynthesis protein cobN. | Cobalamin 5-phosphate synthase cobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.589 |
| CobU_1 | BtuR | RMCT_2679 | RMCT_4279 | Bifunctional cobalamin biosynthesis protein CobU. | cob(I)yrinic acid a,c-diamide adenosyltransferase. | 0.980 |
| CobU_1 | CobN | RMCT_2679 | RMCT_4355 | Bifunctional cobalamin biosynthesis protein CobU. | Cobalamin biosynthesis protein cobN. | 0.606 |