RMCT_3355 protein (Mycolicibacterium thermoresistibile)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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[Homology]

Score

RMCT_3355

20S proteasome, A and B subunits. (232 aa)

Predicted Functional Partners:

arc

0.882

glpK

0.858

Mec

0.842

FtsH2

0.650

EccA1_1

0.650

FtsH3

0.650

EccA1_2

0.650

RMCT_0462

0.603

RMCT_0584

0.603

RMCT_0585

0.603

Your Current Organism:

Mycolicibacterium thermoresistibile

NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EccA1_1	Mec	RMCT_1055	RMCT_2193	Type VII secretion AAA-ATPase EccA.	Mov34/MPN/PAD-1 family protein.	0.678
EccA1_1	RMCT_0462	RMCT_1055	RMCT_0462	Type VII secretion AAA-ATPase EccA.	Putative uncharacterized protein.	0.587
EccA1_1	RMCT_0584	RMCT_1055	RMCT_0584	Type VII secretion AAA-ATPase EccA.	Conserved Mce associated membrane protein.	0.587
EccA1_1	RMCT_0585	RMCT_1055	RMCT_0585	Type VII secretion AAA-ATPase EccA.	Mce associated membrane protein.	0.587
EccA1_1	RMCT_3355	RMCT_1055	RMCT_3355	Type VII secretion AAA-ATPase EccA.	20S proteasome, A and B subunits.	0.650
EccA1_1	arc	RMCT_1055	RMCT_4326	Type VII secretion AAA-ATPase EccA.	ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.665
EccA1_1	glpK	RMCT_1055	RMCT_0079	Type VII secretion AAA-ATPase EccA.	Glycerol kinase GlpK; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.687
EccA1_2	Mec	RMCT_4072	RMCT_2193	ATPase central domain-containing protein.	Mov34/MPN/PAD-1 family protein.	0.635
EccA1_2	RMCT_0462	RMCT_4072	RMCT_0462	ATPase central domain-containing protein.	Putative uncharacterized protein.	0.587
EccA1_2	RMCT_0584	RMCT_4072	RMCT_0584	ATPase central domain-containing protein.	Conserved Mce associated membrane protein.	0.587
EccA1_2	RMCT_0585	RMCT_4072	RMCT_0585	ATPase central domain-containing protein.	Mce associated membrane protein.	0.587
EccA1_2	RMCT_3355	RMCT_4072	RMCT_3355	ATPase central domain-containing protein.	20S proteasome, A and B subunits.	0.650
EccA1_2	arc	RMCT_4072	RMCT_4326	ATPase central domain-containing protein.	ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.665
EccA1_2	glpK	RMCT_4072	RMCT_0079	ATPase central domain-containing protein.	Glycerol kinase GlpK; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.	0.687
FtsH2	Mec	RMCT_0334	RMCT_2193	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	Mov34/MPN/PAD-1 family protein.	0.635
FtsH2	RMCT_0462	RMCT_0334	RMCT_0462	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	Putative uncharacterized protein.	0.587
FtsH2	RMCT_0584	RMCT_0334	RMCT_0584	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	Conserved Mce associated membrane protein.	0.587
FtsH2	RMCT_0585	RMCT_0334	RMCT_0585	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	Mce associated membrane protein.	0.638
FtsH2	RMCT_3355	RMCT_0334	RMCT_3355	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	20S proteasome, A and B subunits.	0.650
FtsH2	arc	RMCT_0334	RMCT_4326	ATPase central domain-containing protein; Belongs to the AAA ATPase family.	ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.	0.665

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