Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MdeA_2Cys/Met metabolism pyridoxal-phosphate-dependent enzyme. (367 aa)    
Predicted Functional Partners:
Cbs
Cystathionine beta-synthase CBS.
 
 0.992
CysK1
Cysteine synthase A cysK1; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.971
MetH
5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.966
CysK
Lyase.
  
 0.962
metE
5- methyltetrahydropteroyltriglutamate/ homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.949
PatB
Aminotransferase.
 
 
 0.941
SseA_2
Thiosulfate sulfurtransferase sseB.
  
 
 0.939
IlvE
Branched-chain amino acid aminotransferase.
  
 0.935
RMCT_1817
Thiosulfate sulfurtransferase.
  
 
 0.921
SseA_1
Thiosulfate sulfurtransferase.
  
 
 0.921
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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