Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Tap_2Exported protease. (499 aa)    
Predicted Functional Partners:
GlnA_1
Glutamine synthetase.
  
  
 0.773
Fgd_2
Fis family transcriptional regulator.
 
  
 0.655
glnE
Glutamate-ammonia-ligase adenylyltransferase glnE; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal t [...]
     
 0.637
PpsA_2
Beta-ketoacyl synthase.
  
 0.587
Pks2
Polyketide synthase pks5.
  
 0.580
Tap_1
Exported protease.
 
    
0.568
RMCT_3804
Protein of unknown function.
  
     0.555
RMCT_2088
Hypothetical protein.
  
 
 0.548
EryA_1
Acyl transferase domain-containing protein.
  
 0.528
RMCT_2286
NUDIX hydrolase.
 
  
 0.512
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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