Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Fgd_2Fis family transcriptional regulator. (286 aa)    
Predicted Functional Partners:
glnE
Glutamate-ammonia-ligase adenylyltransferase glnE; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal t [...]
       0.785
RMCT_4121
F420-dependent oxidoreductase, MSMEG_4879 family.
  
     0.718
GlnA_1
Glutamine synthetase.
       0.690
RutA_2
Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase.
  
   
 0.686
Tap_2
Exported protease.
 
  
 0.655
RMCT_0249
Luciferase family protein.
  
   
 0.615
RMCT_1930
Coenzyme F420-dependent oxidoreductase.
 
     0.607
LimB_4
Luciferase family protein.
  
     0.599
RMCT_2213
F420-dependent oxidoreductase, MSMEG_4879 family.
  
     0.583
RMCT_1886
Nuclear transport factor 2.
 
     0.579
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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