Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
CysG_2Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. (411 aa)    
Predicted Functional Partners:
HemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.996
CysG_1
uroporphyrin-III C-methyltransferase hemD.
 
 
0.995
CobI_1
Precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase; Bifunctional protein, cobI-cobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase; Belongs to the precorrin methyltransferase family.
 
 
 0.989
cysC
Bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
  
 0.981
RMCT_4397
Possible transcriptional regulatory protein.
 
 
 0.980
CbiX
Cobalamin (Vitamin B12) biosynthesis CbiX protein.
 
 
 0.974
hemE
Uroporphyrinogen decarboxylase hemE; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.963
RMCT_4398
Putative uncharacterized protein.
  
 0.960
cobB-3
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.952
HemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.948
Your Current Organism:
Mycolicibacterium thermoresistibile
NCBI taxonomy Id: 1797
Other names: ATCC 19527, CCUG 28008, CCUG 41353, CIP 105390, DSM 44167, JCM 6362, M. thermoresistibile, Mycobacterium thermoresistibile, NCTC 10409
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