| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CysG_2 | MetH | RMCT_4281 | RMCT_3940 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.876 |
| CysG_2 | NarB | RMCT_4281 | RMCT_4395 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Sulfite reductase (NADPH) subunit alpha. | 0.947 |
| CysG_2 | RMCT_4354 | RMCT_4281 | RMCT_4354 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Cobalamin biosynthesis protein cobG. | 0.871 |
| CysG_2 | Sir | RMCT_4281 | RMCT_0782 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Ferredoxin-dependent nitrite reductase nirA; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.943 |
| CysG_2 | ThcD | RMCT_4281 | RMCT_0421 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Ferredoxin reductase. | 0.810 |
| CysG_2 | cysC | RMCT_4281 | RMCT_1372 | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | Bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.981 |
| MetH | CysG_2 | RMCT_3940 | RMCT_4281 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | 0.876 |
| MetH | NarB | RMCT_3940 | RMCT_4395 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Sulfite reductase (NADPH) subunit alpha. | 0.922 |
| MetH | RMCT_3723 | RMCT_3940 | RMCT_3723 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Indolepyruvate ferredoxin oxidoreductase alpha and subunit beta. | 0.433 |
| MetH | RMCT_4354 | RMCT_3940 | RMCT_4354 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cobalamin biosynthesis protein cobG. | 0.522 |
| MetH | Sir | RMCT_3940 | RMCT_0782 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ferredoxin-dependent nitrite reductase nirA; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.522 |
| MetH | cysC | RMCT_3940 | RMCT_1372 | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional sulfate adenyltransferase/adenylylsulfate kinase cysN/cysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.775 |
| NarB | CysG_2 | RMCT_4395 | RMCT_4281 | Sulfite reductase (NADPH) subunit alpha. | Multi-functional enzyme siroheme synthase cysG: uroporphyrin-III C-methyltransferase + precorrin-2 oxidase + ferrochelatase. | 0.947 |
| NarB | MetH | RMCT_4395 | RMCT_3940 | Sulfite reductase (NADPH) subunit alpha. | 5-methyltetrahydrofolate-homocystein methyltransferase metH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.922 |
| NarB | Nqo1_1 | RMCT_4395 | RMCT_3031 | Sulfite reductase (NADPH) subunit alpha. | NADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.918 |
| NarB | Nqo1_2 | RMCT_4395 | RMCT_0987 | Sulfite reductase (NADPH) subunit alpha. | NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. | 0.918 |
| NarB | NuoE | RMCT_4395 | RMCT_3032 | Sulfite reductase (NADPH) subunit alpha. | NADH dehydrogenase subunit E. | 0.940 |
| NarB | RMCT_3723 | RMCT_4395 | RMCT_3723 | Sulfite reductase (NADPH) subunit alpha. | Indolepyruvate ferredoxin oxidoreductase alpha and subunit beta. | 0.960 |
| NarB | RMCT_4354 | RMCT_4395 | RMCT_4354 | Sulfite reductase (NADPH) subunit alpha. | Cobalamin biosynthesis protein cobG. | 0.947 |
| NarB | Sir | RMCT_4395 | RMCT_0782 | Sulfite reductase (NADPH) subunit alpha. | Ferredoxin-dependent nitrite reductase nirA; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.947 |
