node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PabB | TrpG | RMCT_1554 | RMCT_1101 | Para-aminobenzoate synthase component I pabD. | Para-aminobenzoate synthase component II. | 0.999 |
PabB | trpA | RMCT_1554 | RMCT_4434 | Para-aminobenzoate synthase component I pabD. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.924 |
PabB | trpB | RMCT_1554 | RMCT_4433 | Para-aminobenzoate synthase component I pabD. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.930 |
PabB | trpC | RMCT_1554 | RMCT_4432 | Para-aminobenzoate synthase component I pabD. | Indole-3-glycerol phosphate synthase trpC; Belongs to the TrpC family. | 0.982 |
PabB | trpE | RMCT_1554 | RMCT_4430 | Para-aminobenzoate synthase component I pabD. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.855 |
SerB2 | TrpB_2 | RMCT_3593 | RMCT_0227 | Phosphoserine phosphatase SerB. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
SerB2 | glyA | RMCT_3593 | RMCT_1461 | Phosphoserine phosphatase SerB. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.954 |
SerB2 | ilvA | RMCT_3593 | RMCT_4400 | Phosphoserine phosphatase SerB. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.914 |
SerB2 | trpA | RMCT_3593 | RMCT_4434 | Phosphoserine phosphatase SerB. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.917 |
SerB2 | trpB | RMCT_3593 | RMCT_4433 | Phosphoserine phosphatase SerB. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.936 |
TrpB_2 | SerB2 | RMCT_0227 | RMCT_3593 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Phosphoserine phosphatase SerB. | 0.900 |
TrpB_2 | glyA | RMCT_0227 | RMCT_1461 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
TrpB_2 | ilvA | RMCT_0227 | RMCT_4400 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.939 |
TrpB_2 | trpA | RMCT_0227 | RMCT_4434 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.996 |
TrpB_2 | trpB | RMCT_0227 | RMCT_4433 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.929 |
TrpB_2 | trpC | RMCT_0227 | RMCT_4432 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | Indole-3-glycerol phosphate synthase trpC; Belongs to the TrpC family. | 0.948 |
TrpG | PabB | RMCT_1101 | RMCT_1554 | Para-aminobenzoate synthase component II. | Para-aminobenzoate synthase component I pabD. | 0.999 |
TrpG | trpA | RMCT_1101 | RMCT_4434 | Para-aminobenzoate synthase component II. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.975 |
TrpG | trpB | RMCT_1101 | RMCT_4433 | Para-aminobenzoate synthase component II. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.976 |
TrpG | trpC | RMCT_1101 | RMCT_4432 | Para-aminobenzoate synthase component II. | Indole-3-glycerol phosphate synthase trpC; Belongs to the TrpC family. | 0.997 |