STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OGS44586.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)    
Predicted Functional Partners:
fen
Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
   
 0.997
ligA
DNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
     
 0.811
pcn
Proliferating cell nuclear antigen (pcna); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
    
 0.756
OGS42757.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
   
 0.594
OGS44584.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.512
OGS44728.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.501
OGS44587.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.499
polB
Hypothetical protein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 
 0.492
OGS44697.1
DNA polymerase II; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.459
OGS45202.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
   
 0.459
Your Current Organism:
Euryarchaeota archaeon RBG135723
NCBI taxonomy Id: 1797977
Other names: E. archaeon RBG_13_57_23, Euryarchaeota archaeon RBG_13_57_23
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.