STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.993
hemH
Thiamine biosynthesis protein ThiF; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.903
OGV31411.1
EF-P beta-lysylation protein EpmB; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.875
OGV28087.1
Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.831
bioB
Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
   
 
 0.725
OGV28088.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
     
 0.724
OGV35379.1
DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.718
OGV37271.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family.
    
 0.710
OGV36309.1
Delta(24(24(1)))-sterol reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
  
  0.653
OGV30523.1
Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.625
Your Current Organism:
Legionellales bacterium RIFCSPHIGHO212FULL3511
NCBI taxonomy Id: 1798567
Other names: L. bacterium RIFCSPHIGHO2_12_FULL_35_11, Legionellales bacterium RIFCSPHIGHO2_12_FULL_35_11
Server load: low (8%) [HD]