STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lepAElongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (748 aa)    
Predicted Functional Partners:
rpsO
30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
  
 
 0.966
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.961
OGY97124.1
30S ribosomal protein S4; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.959
rplR
50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
   
 
 0.955
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
 
 0.954
OGY96932.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.953
OGY96935.1
30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uS8 family.
   
 
 0.952
OGY96937.1
50S ribosomal protein L5; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the universal ribosomal protein uL5 family.
   
 
 0.952
OGY96949.1
50S ribosomal protein L3; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.952
rpsK
30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
   
 
 0.952
Your Current Organism:
Liptonbacteria bacterium GWB1496
NCBI taxonomy Id: 1798644
Other names: C. Liptonbacteria bacterium GWB1_49_6, Candidatus Liptonbacteria bacterium GWB1_49_6
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.