AZE42_06399 protein (Rhizopogon vesiculosus)

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

AZE42_06399

DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (973 aa)

Predicted Functional Partners:

AZE42_02126

0.999

AZE42_02949

0.998

AZE42_03656

0.995

AZE42_02134

0.988

AZE42_10382

0.983

AZE42_03052

0.954

AZE42_12740

0.954

AZE42_12690

0.954

AZE42_11069

0.954

AZE42_03050

0.954

Your Current Organism:

Rhizopogon vesiculosus

NCBI taxonomy Id: 180088
Other names: R. vesiculosus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZE42_02126	AZE42_02134	A0A1J8R8I6	A0A1J8R321	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.973
AZE42_02126	AZE42_02949	A0A1J8R8I6	A0A1J8QPQ3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.990
AZE42_02126	AZE42_03050	A0A1J8R8I6	A0A1J8QBE7	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.924
AZE42_02126	AZE42_03052	A0A1J8R8I6	A0A1J8PT45	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.924
AZE42_02126	AZE42_03656	A0A1J8R8I6	A0A1J8Q8P6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA_mis_repair domain-containing protein.	0.995
AZE42_02126	AZE42_06399	A0A1J8R8I6	A0A1J8PR41	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.999
AZE42_02126	AZE42_10382	A0A1J8R8I6	A0A1J8QE54	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.998
AZE42_02126	AZE42_11069	A0A1J8R8I6	A0A1J8QB91	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.924
AZE42_02126	AZE42_12690	A0A1J8R8I6	A0A1J8Q7Q6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutL_C domain-containing protein.	0.924
AZE42_02126	AZE42_12740	A0A1J8R8I6	A0A1J8Q2G1	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	Uncharacterized protein.	0.924
AZE42_02134	AZE42_02126	A0A1J8R321	A0A1J8R8I6	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.973
AZE42_02134	AZE42_02949	A0A1J8R321	A0A1J8QPQ3	Uncharacterized protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.867
AZE42_02134	AZE42_03050	A0A1J8R321	A0A1J8QBE7	Uncharacterized protein.	Uncharacterized protein.	0.881
AZE42_02134	AZE42_03052	A0A1J8R321	A0A1J8PT45	Uncharacterized protein.	Uncharacterized protein.	0.881
AZE42_02134	AZE42_03656	A0A1J8R321	A0A1J8Q8P6	Uncharacterized protein.	DNA_mis_repair domain-containing protein.	0.987
AZE42_02134	AZE42_06399	A0A1J8R321	A0A1J8PR41	Uncharacterized protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.988
AZE42_02134	AZE42_10382	A0A1J8R321	A0A1J8QE54	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.978
AZE42_02134	AZE42_11069	A0A1J8R321	A0A1J8QB91	Uncharacterized protein.	Uncharacterized protein.	0.881
AZE42_02134	AZE42_12690	A0A1J8R321	A0A1J8Q7Q6	Uncharacterized protein.	MutL_C domain-containing protein.	0.881
AZE42_02134	AZE42_12740	A0A1J8R321	A0A1J8Q2G1	Uncharacterized protein.	Uncharacterized protein.	0.881

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.856

expected number of edges:

18

PPI enrichment p-value:

0.0139

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032508

DNA duplex unwinding

4 of 51

2.01

1.8

0.00026

GO:0000723

Telomere maintenance

3 of 36

2.04

1.42

0.0018

GO:0070199

Establishment of protein localization to chromosome

2 of 6

2.64

1.35

0.0035

GO:0007004

Telomere maintenance via telomerase

2 of 5

2.72

1.35

0.0035

GO:2000573

Positive regulation of DNA biosynthetic process

2 of 9

2.47

1.25

0.0051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043047

Single-stranded telomeric DNA binding

2 of 4

2.82

1.21

0.0063

GO:0140097

Catalytic activity, acting on DNA

4 of 151

1.54

1.02

0.0063

GO:0009982

Pseudouridine synthase activity

2 of 10

2.42

1.01

0.0139

GO:0008094

ATP-dependent activity, acting on DNA

3 of 88

1.65

0.91

0.0139

GO:0004520

Endodeoxyribonuclease activity

2 of 21

2.1

0.88

0.0227

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030870

Mre11 complex

2 of 2

3.12

1.41

0.0029

GO:0005694

Chromosome

5 of 360

1.26

0.97

0.0029

GO:0005657

Replication fork

2 of 27

1.99

0.82

0.0280

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 1612

0.76

0.5

0.0145

GO:0070013

Intracellular organelle lumen

5 of 993

0.82

0.46

0.0427

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5386

Homologous DNA Pairing and Strand Exchange, and Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

3 of 20

2.3

1.89

0.00026

CL:5382

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and DNA polymerase complex

4 of 60

1.94

1.81

0.00021

CL:5399

Sensing of DNA Double Strand Breaks, and D-loop DNA binding

2 of 5

2.72

1.48

0.0020

CL:7848

Box H/ACA RNP complex, and Box H/ACA snoRNP assembly

2 of 6

2.64

1.42

0.0025

CL:4172

Protein palmitoylation, and Telomere assembly

2 of 11

2.38

1.19

0.0063

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03450

Non-homologous end-joining

2 of 12

2.34

1.16

0.0072

map03440

Homologous recombination

2 of 54

1.69

0.67

0.0496

map03030

DNA replication

2 of 49

1.73

0.67

0.0496

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685938

HDR through Single Strand Annealing (SSA)

4 of 26

2.31

2.7

5.73e-06

MAP-180786

Extension of Telomeres

4 of 28

2.28

2.68

5.73e-06

MAP-157579

Telomere Maintenance

4 of 35

2.18

2.63

5.73e-06

MAP-5693607

Processing of DNA double-strand break ends

4 of 36

2.17

2.62

5.73e-06

MAP-5685942

HDR through Homologous Recombination (HRR)

4 of 39

2.13

2.6

5.73e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030870

Mre11 complex

2 of 5

2.72

1.09

0.0106

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