OGH98085.1 protein (Melainabacteria bacterium GWA2349)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

OGH98085.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (205 aa)

Predicted Functional Partners:

OGH98084.1

0.476

OGH98091.1

0.409

Your Current Organism:

Melainabacteria bacterium GWA2349

NCBI taxonomy Id: 1801604
Other names: C. Melainabacteria bacterium GWA2_34_9, Candidatus Melainabacteria bacterium GWA2_34_9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGH98084.1	OGH98085.1	A2039_07750	A2039_07755	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
OGH98084.1	OGH98091.1	A2039_07750	A2039_07745	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.648
OGH98085.1	OGH98084.1	A2039_07755	A2039_07750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
OGH98085.1	OGH98091.1	A2039_07755	A2039_07745	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
OGH98091.1	OGH98084.1	A2039_07745	A2039_07750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.648
OGH98091.1	OGH98085.1	A2039_07745	A2039_07755	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.409

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000467

Exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

11 of 14

2.68

11.66

4.48e-25

GO:0071038

Nuclear polyadenylation-dependent tRNA catabolic process

11 of 16

2.62

11.42

4.48e-25

GO:0016075

rRNA catabolic process

11 of 25

2.43

10.12

5.49e-24

GO:0071035

Nuclear polyadenylation-dependent rRNA catabolic process

9 of 15

2.56

9.01

1.41e-19

GO:0034427

Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5

8 of 13

2.58

8.0

4.15e-17

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 460

1.17

1.7

2.37e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000176

Nuclear exosome (RNase complex)

11 of 12

2.75

12.38

3.33e-26

GO:0000177

Cytoplasmic exosome (RNase complex)

10 of 12

2.71

11.0

2.68e-23

GO:0005730

Nucleolus

11 of 227

1.47

3.06

1.36e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3967

Exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

11 of 13

2.71

12.08

8.47e-26

CL:3971

Nuclear exosome (RNase complex)

8 of 8

2.79

8.76

7.38e-18

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

11 of 89

1.88

5.68

6.12e-19

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-450513

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

10 of 13

2.67

10.51

2.10e-22

MAP-450385

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

10 of 15

2.61

10.24

3.00e-22

MAP-429958

mRNA decay by 3 to 5 exoribonuclease

10 of 19

2.51

9.62

1.22e-21

MAP-450531

Regulation of mRNA stability by proteins that bind AU-rich elements

10 of 26

2.37

8.71

1.16e-20

MAP-429914

Deadenylation-dependent mRNA decay

10 of 40

2.18

7.37

3.76e-19

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000178

Exosome (RNase complex)

11 of 14

2.68

11.89

1.22e-25

GOCC:0000176

Nuclear exosome (RNase complex)

7 of 7

2.79

7.55

2.66e-15

GOCC:0000177

Cytoplasmic exosome (RNase complex)

6 of 8

2.66

5.99

2.35e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0269

Exonuclease

2 of 6

2.31

0.98

0.0153

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01138

3 exoribonuclease family, domain 1

6 of 6

2.79

6.1

2.47e-12

PF15985

KH domain

2 of 2

2.79

1.25

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027408

PNPase/RNase PH domain superfamily

6 of 6

2.79

5.86

7.48e-12

IPR001247

Exoribonuclease, phosphorolytic domain 1

6 of 6

2.79

5.86

7.48e-12

IPR020568

Ribosomal protein S5 domain 2-type fold

6 of 29

2.1

3.84

4.32e-09

IPR036345

Exoribonuclease, PH domain 2 superfamily

3 of 3

2.79

2.42

3.69e-05

IPR012340

Nucleic acid-binding, OB-fold

4 of 52

1.67

1.46

0.00062

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00316

Ribosomal protein S1-like RNA-binding domain

2 of 5

2.39

1.03

0.0130

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