node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SJZ33225.1 | ffh | SAMN02745174_00045 | SAMN02745174_00046 | Hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.943 |
SJZ33225.1 | rpsP | SAMN02745174_00045 | SAMN02745174_00047 | Hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. | Small subunit ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | 0.659 |
SJZ45713.1 | SKA00718.1 | SAMN02745174_00581 | SAMN02745174_02253 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | 0.972 |
SJZ45713.1 | ffh | SAMN02745174_00581 | SAMN02745174_00046 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.887 |
SJZ45713.1 | ftsY | SAMN02745174_00581 | SAMN02745174_00540 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Fused signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.894 |
SJZ45713.1 | rplD | SAMN02745174_00581 | SAMN02745174_02146 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Large subunit ribosomal protein L4; Forms part of the polypeptide exit tunnel. | 0.714 |
SJZ45713.1 | rplM | SAMN02745174_00581 | SAMN02745174_00653 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.908 |
SJZ45713.1 | rplN | SAMN02745174_00581 | SAMN02745174_02155 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.688 |
SJZ45713.1 | rplO | SAMN02745174_00581 | SAMN02745174_02164 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.694 |
SJZ45713.1 | secY | SAMN02745174_00581 | SAMN02745174_02165 | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.936 |
SKA00718.1 | SJZ45713.1 | SAMN02745174_02253 | SAMN02745174_00581 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. | 0.972 |
SKA00718.1 | ffh | SAMN02745174_02253 | SAMN02745174_00046 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.899 |
SKA00718.1 | ftsY | SAMN02745174_02253 | SAMN02745174_00540 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Fused signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.887 |
SKA00718.1 | rplD | SAMN02745174_02253 | SAMN02745174_02146 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Large subunit ribosomal protein L4; Forms part of the polypeptide exit tunnel. | 0.926 |
SKA00718.1 | rplM | SAMN02745174_02253 | SAMN02745174_00653 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.932 |
SKA00718.1 | rplN | SAMN02745174_02253 | SAMN02745174_02155 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. | 0.824 |
SKA00718.1 | rplO | SAMN02745174_02253 | SAMN02745174_02164 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.939 |
SKA00718.1 | rpsP | SAMN02745174_02253 | SAMN02745174_00047 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Small subunit ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | 0.779 |
SKA00718.1 | secY | SAMN02745174_02253 | SAMN02745174_02165 | Preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. | Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.965 |
ffh | SJZ33225.1 | SAMN02745174_00046 | SAMN02745174_00045 | Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Hypothetical protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. | 0.943 |