OGW10978.1 protein (Nitrospinae bacterium RIFCSPLOWO2123915)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

OGW10978.1

Type III-A CRISPR-associated RAMP protein Csm3; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)

Predicted Functional Partners:

OGW10977.1

0.999

OGW10980.1

0.998

OGW10979.1

0.997

OGW10409.1

0.800

OGW07770.1

0.749

OGW07771.1

0.748

OGW08176.1

0.709

OGW10981.1

0.701

OGW10982.1

0.701

OGW08185.1

0.598

Your Current Organism:

Nitrospinae bacterium RIFCSPLOWO2123915

NCBI taxonomy Id: 1801689
Other names: N. bacterium RIFCSPLOWO2_12_39_15, Nitrospinae bacterium RIFCSPLOWO2_12_39_15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGW07770.1	OGW07771.1	A2W75_01745	A2W75_01750	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OGW07770.1	OGW08185.1	A2W75_01745	A2W75_03825	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.794
OGW07770.1	OGW10409.1	A2W75_01745	A2W75_02610	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.769
OGW07770.1	OGW10977.1	A2W75_01745	A2W75_00645	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.624
OGW07770.1	OGW10978.1	A2W75_01745	A2W75_00650	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III-A CRISPR-associated RAMP protein Csm3; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.749
OGW07770.1	OGW10980.1	A2W75_01745	A2W75_00660	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III-A CRISPR-associated protein Cas10/Csm1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.781
OGW07771.1	OGW07770.1	A2W75_01750	A2W75_01745	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OGW07771.1	OGW08185.1	A2W75_01750	A2W75_03825	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.728
OGW07771.1	OGW10409.1	A2W75_01750	A2W75_02610	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.832
OGW07771.1	OGW10977.1	A2W75_01750	A2W75_00645	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.731
OGW07771.1	OGW10978.1	A2W75_01750	A2W75_00650	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III-A CRISPR-associated RAMP protein Csm3; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.748
OGW07771.1	OGW10980.1	A2W75_01750	A2W75_00660	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III-A CRISPR-associated protein Cas10/Csm1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
OGW08176.1	OGW08185.1	A2W75_03775	A2W75_03825	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.825
OGW08176.1	OGW10409.1	A2W75_03775	A2W75_02610	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.409
OGW08176.1	OGW10977.1	A2W75_03775	A2W75_00645	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.556
OGW08176.1	OGW10978.1	A2W75_03775	A2W75_00650	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Type III-A CRISPR-associated RAMP protein Csm3; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.709
OGW08176.1	OGW10980.1	A2W75_03775	A2W75_00660	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Type III-A CRISPR-associated protein Cas10/Csm1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.745
OGW08185.1	OGW07770.1	A2W75_03825	A2W75_01745	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	CRISPR-associated endonuclease Cas1; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.794
OGW08185.1	OGW07771.1	A2W75_03825	A2W75_01750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	CRISPR-associated endonuclease Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.728
OGW08185.1	OGW08176.1	A2W75_03825	A2W75_03775	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	CRISPR-associated endoribonuclease Cas6; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.825

page 1 of 4

Network Stats

number of nodes:

4

number of edges:

5

average node degree:

2.5

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004129

Cytochrome-c oxidase activity

3 of 5

2.22

1.54

0.0012

GO:0005507

Copper ion binding

2 of 8

1.84

0.7

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

8 of 410

0.74

0.58

0.0017

GO:0016021

Integral component of membrane

8 of 680

0.52

0.35

0.0233

GO:0016020

Membrane

9 of 975

0.41

0.29

0.0259

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24804722

(2014) Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.

2 of 2

2.44

1.5

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2145

Copper, and Heme biosynthesis

7 of 7

2.44

5.78

1.58e-12

CL:2078

Oxidative phosphorylation, and Peptidase M16, C-terminal

9 of 42

1.78

4.0

1.58e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mmr00190

Oxidative phosphorylation

6 of 44

1.58

2.25

6.39e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0186

Copper

3 of 3

2.44

2.06

0.00014

KW-0679

Respiratory chain

2 of 5

2.05

1.09

0.0086

KW-0350

Heme biosynthesis

2 of 5

2.05

1.09

0.0086

KW-1003

Cell membrane

5 of 140

1.0

0.76

0.0034

KW-1133

Transmembrane helix

9 of 581

0.63

0.5

0.0013

(more ...)

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