OHC84908.1 protein (Sphingobacteriia bacterium RIFOXYC2FULL3518)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

OHC84908.1

ADP-glyceromanno-heptose 6-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)

Predicted Functional Partners:

OHC84876.1

0.946

OHC84893.1

0.944

OHC84880.1

0.943

OHC84885.1

0.943

OHC84890.1

0.943

OHC85400.1

0.942

OHC84872.1

0.942

OHC84875.1

0.941

OHC84883.1

0.941

OHC86481.1

0.939

Your Current Organism:

Sphingobacteriia bacterium RIFOXYC2FULL3518

NCBI taxonomy Id: 1802166
Other names: S. bacterium RIFOXYC2_FULL_35_18, Sphingobacteriia bacterium RIFOXYC2_FULL_35_18

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OHC84872.1	OHC84875.1	A2472_14350	A2472_14365	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84876.1	A2472_14350	A2472_14370	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S14; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84880.1	A2472_14350	A2472_14390	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S17; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84883.1	A2472_14350	A2472_14405	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S3; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84885.1	A2472_14350	A2472_14415	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S19; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84890.1	A2472_14350	A2472_14440	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S10; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84893.1	A2472_14350	A2472_14455	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S12; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC84908.1	A2472_14350	A2472_14535	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	ADP-glyceromanno-heptose 6-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.942
OHC84872.1	OHC85400.1	A2472_14350	A2472_06455	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S13; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84872.1	OHC86481.1	A2472_14350	A2472_02635	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84872.1	A2472_14365	A2472_14350	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S5; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84876.1	A2472_14365	A2472_14370	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S14; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84880.1	A2472_14365	A2472_14390	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S17; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84883.1	A2472_14365	A2472_14405	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S3; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84885.1	A2472_14365	A2472_14415	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S19; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84890.1	A2472_14365	A2472_14440	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S10; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84893.1	A2472_14365	A2472_14455	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S12; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC84908.1	A2472_14365	A2472_14535	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	ADP-glyceromanno-heptose 6-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.941
OHC84875.1	OHC85400.1	A2472_14365	A2472_06455	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S13; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OHC84875.1	OHC86481.1	A2472_14365	A2472_02635	30S ribosomal protein S8; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.898

expected number of edges:

22

PPI enrichment p-value:

0.00803

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

5 of 38

2.08

3.26

1.16e-07

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

8 of 153

1.68

3.22

3.00e-10

GO:0006511

Ubiquitin-dependent protein catabolic process

9 of 226

1.56

2.87

2.94e-10

GO:0035967

Cellular response to topologically incorrect protein

4 of 31

2.07

2.53

6.40e-06

GO:0071712

ER-associated misfolded protein catabolic process

2 of 5

2.57

1.43

0.0024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032182

Ubiquitin-like protein binding

4 of 36

2.01

2.0

9.11e-05

GO:0043130

Ubiquitin binding

3 of 33

1.92

1.2

0.0045

GO:0051787

Misfolded protein binding

2 of 9

2.31

0.93

0.0198

GO:0031593

Polyubiquitin modification-dependent protein binding

2 of 13

2.15

0.82

0.0301

GO:0005515

Protein binding

7 of 973

0.82

0.57

0.0082

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

6 of 258

1.33

1.39

9.79e-05

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

2 of 5

2.57

1.38

0.0030

GO:0043231

Intracellular membrane-bounded organelle

10 of 3845

0.38

0.27

0.0406

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8282

ERAD pathway, and Hedgehog ligand biogenesis

9 of 39

2.33

7.29

4.33e-17

CL:8286

UBX domain, and VCP-NPL4-UFD1 AAA ATPase complex

6 of 13

2.63

5.99

2.01e-12

CL:8333

Derlin, and Protein OS-9-like

3 of 5

2.74

2.72

9.63e-06

CL:8288

VCP-NPL4-UFD1 AAA ATPase complex, and PUL domain

3 of 5

2.74

2.72

9.63e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

9 of 189

1.64

3.46

2.61e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9755511

KEAP1-NFE2L2 pathway

4 of 25

2.17

2.41

1.64e-05

MAP-9711123

Cellular response to chemical stress

4 of 68

1.73

1.62

0.00030

MAP-8951664

Neddylation

4 of 94

1.59

1.42

0.00060

MAP-597592

Post-translational protein modification

7 of 591

1.04

0.95

0.00030

MAP-5689896

Ovarian tumor domain proteases

2 of 17

2.03

0.92

0.0188

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000836

Hrd1p ubiquitin ligase complex

3 of 12

2.36

2.04

0.00014

GOCC:0005789

Endoplasmic reticulum membrane

5 of 120

1.58

1.65

0.00011

GOCC:0034098

VCP-NPL4-UFD1 AAA ATPase complex

2 of 5

2.57

1.43

0.0024

GOCC:0000839

Hrd1p ubiquitin ligase ERAD-L complex

2 of 6

2.49

1.4

0.0027

GOCC:0005783

Endoplasmic reticulum

5 of 209

1.34

1.3

0.00028

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04511

Der1-like family

2 of 2

2.96

1.23

0.0060

PF14555

UBA-like domain

2 of 4

2.66

1.17

0.0075

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007599

Derlin

2 of 2

2.96

0.98

0.0172

IPR029071

Ubiquitin-like domain superfamily

3 of 36

1.88

0.92

0.0172

IPR001012

UBX domain

2 of 6

2.49

0.86

0.0267

IPR035952

Rhomboid-like superfamily

2 of 10

2.26

0.72

0.0470

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00166

Domain present in ubiquitin-regulatory proteins

2 of 6

2.49

1.13

0.0087

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