OGL65484.1 protein (Tectomicrobia bacterium RIFCSPLOWO202FULL7019)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

OGL65484.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)

Predicted Functional Partners:

OGL65483.1

0.825

OGL65482.1

0.671

OGL62199.1

0.557

OGL60090.1

0.515

OGL60091.1

0.449

OGL64188.1

0.443

OGL58543.1

0.442

OGL58759.1

0.432

OGL58542.1

0.428

Your Current Organism:

Tectomicrobia bacterium RIFCSPLOWO202FULL7019

NCBI taxonomy Id: 1802342
Other names: C. Tectomicrobia bacterium RIFCSPLOWO2_02_FULL_70_19, Candidatus Tectomicrobia bacterium RIFCSPLOWO2_02_FULL_70_19

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGL58542.1	OGL58543.1	A3I72_15200	A3I72_15205	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.888
OGL58542.1	OGL58759.1	A3I72_15200	A3I72_12750	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
OGL58542.1	OGL60090.1	A3I72_15200	A3I72_08060	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.608
OGL58542.1	OGL60091.1	A3I72_15200	A3I72_08065	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
OGL58542.1	OGL62199.1	A3I72_15200	A3I72_01670	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.403
OGL58542.1	OGL64188.1	A3I72_15200	A3I72_00455	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
OGL58542.1	OGL65484.1	A3I72_15200	A3I72_00750	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.428
OGL58543.1	OGL58542.1	A3I72_15205	A3I72_15200	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.888
OGL58543.1	OGL60091.1	A3I72_15205	A3I72_08065	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.491
OGL58543.1	OGL62199.1	A3I72_15205	A3I72_01670	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
OGL58543.1	OGL64188.1	A3I72_15205	A3I72_00455	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
OGL58543.1	OGL65484.1	A3I72_15205	A3I72_00750	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.442
OGL58759.1	OGL58542.1	A3I72_12750	A3I72_15200	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
OGL58759.1	OGL60090.1	A3I72_12750	A3I72_08060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.439
OGL58759.1	OGL60091.1	A3I72_12750	A3I72_08065	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.508
OGL58759.1	OGL62199.1	A3I72_12750	A3I72_01670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.552
OGL58759.1	OGL64188.1	A3I72_12750	A3I72_00455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.488
OGL58759.1	OGL65484.1	A3I72_12750	A3I72_00750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.432
OGL60090.1	OGL58542.1	A3I72_08060	A3I72_15200	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.608
OGL60090.1	OGL58759.1	A3I72_08060	A3I72_12750	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.439

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.889

expected number of edges:

11

PPI enrichment p-value:

0.126

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006265

DNA topological change

3 of 5

2.24

1.7

0.00059

GO:0006259

DNA metabolic process

6 of 113

1.19

1.09

0.00048

GO:0090304

Nucleic acid metabolic process

8 of 253

0.97

0.88

0.00024

GO:0006260

DNA replication

3 of 35

1.4

0.78

0.0194

GO:0006725

Cellular aromatic compound metabolic process

9 of 488

0.73

0.61

0.00059

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003918

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

3 of 4

2.34

1.7

0.00064

GO:0140097

Catalytic activity, acting on DNA

4 of 64

1.26

1.03

0.0018

GO:0140640

Catalytic activity, acting on a nucleic acid

6 of 148

1.07

0.95

0.00064

GO:0003677

DNA binding

7 of 213

0.98

0.85

0.00064

GO:0140657

ATP-dependent activity

4 of 86

1.13

0.83

0.0046

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005694

Chromosome

3 of 18

1.69

1.14

0.0042

GO:0005737

Cytoplasm

9 of 968

0.43

0.3

0.0343

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:17488508

(2007) Phylogeny and molecular signatures (conserved proteins and indels) that are specific for the Bacteroidetes and Chlorobi species.

2 of 7

1.92

1.33

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2208

DNA topoisomerase, type IIA-like domain superfamily, and Large-conductance mechanosensitive channel

3 of 7

2.1

1.35

0.0026

CL:1844

Translation, and ATP-dependent activity

6 of 189

0.97

0.69

0.0061

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0799

Topoisomerase

3 of 5

2.24

1.83

0.00032

KW-0235

DNA replication

3 of 16

1.74

1.34

0.0016

KW-0238

DNA-binding

5 of 122

1.08

0.88

0.0016

KW-0067

ATP-binding

6 of 190

0.96

0.78

0.0016

KW-0963

Cytoplasm

6 of 200

0.94

0.76

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013760

DNA topoisomerase, type IIA-like domain superfamily

3 of 4

2.34

1.54

0.0013

IPR013758

DNA topoisomerase, type IIA, domain A, alpha-beta

2 of 2

2.47

0.77

0.0393

IPR013757

DNA topoisomerase, type IIA, alpha-helical domain superfamily

2 of 2

2.47

0.77

0.0393

IPR002205

DNA topoisomerase, type IIA, domain A

2 of 2

2.47

0.77

0.0393

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00434

DNA Topoisomerase IV

2 of 2

2.47

1.21

0.0059

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