OGC10734.1 protein (candidate division WOR1 bacterium RIFCSPHIGHO202FULL5326)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Score

OGC10734.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (290 aa)

Predicted Functional Partners:

OGC10733.1

0.773

OGC10732.1

0.625

OGC10735.1

0.473

OGC10736.1

0.408

Your Current Organism:

candidate division WOR1 bacterium RIFCSPHIGHO202FULL5326

NCBI taxonomy Id: 1802566
Other names: c. division WOR-1 bacterium RIFCSPHIGHO2_02_FULL_53_26, candidate division WOR-1 bacterium RIFCSPHIGHO2_02_FULL_53_26

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGC10732.1	OGC10733.1	A3D23_04545	A3D23_04550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.625
OGC10732.1	OGC10734.1	A3D23_04545	A3D23_04555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.625
OGC10733.1	OGC10732.1	A3D23_04550	A3D23_04545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.625
OGC10733.1	OGC10734.1	A3D23_04550	A3D23_04555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGC10733.1	OGC10735.1	A3D23_04550	A3D23_04560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.473
OGC10733.1	OGC10736.1	A3D23_04550	A3D23_04565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.408
OGC10734.1	OGC10732.1	A3D23_04555	A3D23_04545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.625
OGC10734.1	OGC10733.1	A3D23_04555	A3D23_04550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGC10734.1	OGC10735.1	A3D23_04555	A3D23_04560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.473
OGC10734.1	OGC10736.1	A3D23_04555	A3D23_04565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.408
OGC10735.1	OGC10733.1	A3D23_04560	A3D23_04550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.473
OGC10735.1	OGC10734.1	A3D23_04560	A3D23_04555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.473
OGC10735.1	OGC10736.1	A3D23_04560	A3D23_04565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651
OGC10736.1	OGC10733.1	A3D23_04565	A3D23_04550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.408
OGC10736.1	OGC10734.1	A3D23_04565	A3D23_04555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.408
OGC10736.1	OGC10735.1	A3D23_04565	A3D23_04560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.651

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.668

expected number of edges:

11

PPI enrichment p-value:

5.94e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006261

DNA-templated DNA replication

6 of 74

1.97

3.29

3.66e-08

GO:0006273

Lagging strand elongation

3 of 7

2.69

2.49

2.56e-05

GO:0006259

DNA metabolic process

8 of 286

1.51

2.36

3.66e-08

GO:0006275

Regulation of DNA replication

3 of 15

2.36

2.07

0.00012

GO:0006281

DNA repair

6 of 210

1.52

1.89

7.59e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003677

DNA binding

9 of 521

1.3

1.89

2.36e-08

GO:0030337

DNA polymerase processivity factor activity

2 of 2

3.06

1.53

0.0017

GO:0008094

ATP-dependent activity, acting on DNA

3 of 56

1.79

1.23

0.0032

GO:0003678

DNA helicase activity

2 of 24

1.98

0.78

0.0346

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005657

Replication fork

5 of 37

2.19

3.39

1.09e-07

GO:0005694

Chromosome

7 of 307

1.42

1.95

6.24e-07

GO:0043626

PCNA complex

2 of 2

3.06

1.66

0.0010

GO:0032993

protein-DNA complex

3 of 50

1.84

1.43

0.0012

GO:0043601

Nuclear replisome

2 of 14

2.22

1.22

0.0052

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8959

DNA replication, and HDR through Homologous Recombination (HRR)

10 of 141

1.91

5.24

7.99e-16

CL:8961

DNA replication, and HDR through Homologous Recombination (HRR)

9 of 126

1.91

4.9

3.13e-14

CL:8965

DNA-templated DNA replication, and Regulation of DNA replication

5 of 61

1.97

2.91

4.23e-07

CL:9102

HDR through Single Strand Annealing (SSA), and Condensed nuclear chromosome

4 of 30

2.19

2.76

3.01e-06

CL:9107

Mixed, incl. Resolution of D-Loop Structures, and Sensing of DNA Double Strand Breaks

3 of 17

2.31

2.15

7.85e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

5 of 74

1.89

2.77

5.18e-07

map03430

Mismatch repair

4 of 40

2.06

2.67

2.85e-06

map03420

Nucleotide excision repair

4 of 58

1.9

2.36

7.75e-06

map03440

Homologous recombination

3 of 81

1.63

1.28

0.0016

map03410

Base excision repair

2 of 35

1.82

0.97

0.0125

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69166

Removal of the Flap Intermediate

5 of 23

2.4

3.96

1.47e-08

MAP-69183

Processive synthesis on the lagging strand

5 of 24

2.38

3.95

1.47e-08

MAP-69186

Lagging Strand Synthesis

5 of 31

2.27

3.8

1.87e-08

MAP-69190

DNA strand elongation

5 of 35

2.22

3.73

1.96e-08

MAP-69306

DNA Replication

6 of 89

1.89

3.25

1.87e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043596

Nuclear replication fork

3 of 19

2.26

1.82

0.00035

GOCC:0043626

PCNA complex

2 of 2

3.06

1.72

0.00078

GOCC:0005694

Chromosome

6 of 290

1.38

1.49

6.17e-05

GOCC:0000228

Nuclear chromosome

4 of 107

1.63

1.45

0.00056

GOCC:0043601

Nuclear replisome

2 of 13

2.25

1.19

0.0061

(more ...)

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