OGC10370.1 protein (candidate division WOR1 bacterium RIFCSPHIGHO202FULL5326)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

OGC10370.1

Flagellar basal body rod protein FlgC; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)

Predicted Functional Partners:

OGC10368.1

0.998

OGC10374.1

0.997

OGC10375.1

0.997

OGC10377.1

0.997

OGC10378.1

0.997

OGC10371.1

0.996

OGC10851.1

0.994

OGC10848.1

0.991

OGC10853.1

0.988

OGC10365.1

0.988

Your Current Organism:

candidate division WOR1 bacterium RIFCSPHIGHO202FULL5326

NCBI taxonomy Id: 1802566
Other names: c. division WOR-1 bacterium RIFCSPHIGHO2_02_FULL_53_26, candidate division WOR-1 bacterium RIFCSPHIGHO2_02_FULL_53_26

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGC10365.1	OGC10368.1	A3D23_07525	A3D23_07540	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.995
OGC10365.1	OGC10370.1	A3D23_07525	A3D23_07550	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar basal body rod protein FlgC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.988
OGC10365.1	OGC10371.1	A3D23_07525	A3D23_07555	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.957
OGC10365.1	OGC10374.1	A3D23_07525	A3D23_07570	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.938
OGC10365.1	OGC10375.1	A3D23_07525	A3D23_07575	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.933
OGC10365.1	OGC10377.1	A3D23_07525	A3D23_07585	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar basal-body rod protein FlgG; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.932
OGC10365.1	OGC10378.1	A3D23_07525	A3D23_07590	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.934
OGC10365.1	OGC10848.1	A3D23_07525	A3D23_05205	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.971
OGC10365.1	OGC10851.1	A3D23_07525	A3D23_05220	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flagellar motor switch protein FliN; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.994
OGC10365.1	OGC10853.1	A3D23_07525	A3D23_05230	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.923
OGC10368.1	OGC10365.1	A3D23_07540	A3D23_07525	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
OGC10368.1	OGC10370.1	A3D23_07540	A3D23_07550	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Flagellar basal body rod protein FlgC; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
OGC10368.1	OGC10371.1	A3D23_07540	A3D23_07555	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.994
OGC10368.1	OGC10374.1	A3D23_07540	A3D23_07570	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
OGC10368.1	OGC10375.1	A3D23_07540	A3D23_07575	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.997
OGC10368.1	OGC10377.1	A3D23_07540	A3D23_07585	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Flagellar basal-body rod protein FlgG; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
OGC10368.1	OGC10378.1	A3D23_07540	A3D23_07590	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.990
OGC10368.1	OGC10848.1	A3D23_07540	A3D23_05205	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
OGC10368.1	OGC10851.1	A3D23_07540	A3D23_05220	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Flagellar motor switch protein FliN; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.992
OGC10368.1	OGC10853.1	A3D23_07540	A3D23_05230	Flagellar M-ring protein FliF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.975

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

64

PPI enrichment p-value:

0.197

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 110

1.41

1.54

5.45e-05

GO:0050896

Response to stimulus

7 of 395

0.92

0.83

0.00031

GO:0050794

Regulation of cellular process

8 of 483

0.9

0.82

0.00018

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

6 of 120

1.37

1.5

5.15e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2551

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and CheY-like superfamily

10 of 62

1.88

5.18

3.72e-16

CL:2530

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily, and Nucleotide cyclase

11 of 104

1.7

4.29

3.72e-16

CL:2659

PAS fold-4, and EAL domain

4 of 5

2.58

3.81

5.50e-08

CL:2560

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and CheY-like superfamily

5 of 43

1.74

2.48

9.28e-07

CL:2562

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain), and CheY-like superfamily

4 of 37

1.71

1.93

3.68e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

7 of 390

0.93

0.82

0.00044

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 134

1.45

2.33

8.27e-09

KW-0175

Coiled coil

7 of 561

0.77

0.57

0.0042

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000014

PAS domain

7 of 57

1.77

3.03

1.57e-08

IPR035965

PAS domain superfamily

7 of 59

1.75

2.99

1.57e-08

IPR036641

HPT domain superfamily

4 of 14

2.13

2.51

8.93e-06

IPR008207

Signal transduction histidine kinase, phosphotransfer (Hpt) domain

4 of 14

2.13

2.51

8.93e-06

IPR000700

PAS-associated, C-terminal

5 of 36

1.82

2.4

3.45e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00091

PAS domain

7 of 58

1.76

3.28

1.39e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 43

1.82

3.2

9.79e-09

SM00073

Histidine Phosphotransfer domain

4 of 12

2.2

3.06

6.35e-07

SM00448

cheY-homologous receiver domain

8 of 125

1.48

2.52

1.47e-09

SM00388

His Kinase A (phosphoacceptor) domain

6 of 122

1.37

1.76

2.13e-06

(more ...)

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