STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sigKUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (205 aa)    
Predicted Functional Partners:
spo0A
Unannotated protein; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.852
GCA_000797495_04025
Unannotated protein; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
 
   
 0.844
spoIIAA
Unannotated protein; Belongs to the anti-sigma-factor antagonist family.
 
   
 0.803
spoIIAB
Unannotated protein; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
   
 0.802
spoIIID
Unannotated protein.
  
   
 0.779
spoIIE
Unannotated protein.
  
   
 0.777
GCA_000797495_00328
Unannotated protein.
  
     0.774
spoVAD
Unannotated protein.
  
     0.774
GCA_000797495_00330
Unannotated protein.
  
     0.774
spoIVA
Unannotated protein.
  
     0.774
Your Current Organism:
Robinsoniella peoriensis
NCBI taxonomy Id: 180332
Other names: CCUG 48729, Clostridium sp. CCUG 52336, NRRL B-23985, R. peoriensis, Robinsoniella peoriensis Cotta et al. 2009, strain PPC31, swine fecal bacterium FPC47, swine fecal bacterium FPC50, swine manure pit bacterium PPC108, swine manure pit bacterium PPC31, swine manure pit bacterium PPC37, swine manure pit bacterium PPC44
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.