STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OIO14864.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (278 aa)    
Predicted Functional Partners:
guaA
Glutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.754
OIO15410.1
IMP dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IMPDH/GMPR family.
    
  0.679
OIO13605.1
Hypothetical protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
    
  0.679
OIO14455.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.677
pyrF
Orotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily.
    
  0.650
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
  0.625
OIO15419.1
Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.615
OIO14865.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
       0.544
OIO13779.1
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
    
  0.505
Your Current Organism:
Gottesmanbacteria bacterium CG1023722
NCBI taxonomy Id: 1805209
Other names: C. Gottesmanbacteria bacterium CG1_02_37_22, Candidatus Gottesmanbacteria bacterium CG1_02_37_22
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