NEDG_00777 protein (Nematocida displodere) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NEDG_00777

Protein transport protein SEC24. (700 aa)

Predicted Functional Partners:

NEDG_00759

0.999

NEDG_00843

0.999

NEDG_00229

0.999

NEDG_00811

0.987

NEDG_01746

0.982

NEDG_00414

0.926

NEDG_01433

0.727

NEDG_00136

0.724

NEDG_01672

0.635

NEDG_02050

0.621

Your Current Organism:

Nematocida displodere

NCBI taxonomy Id: 1805483
Other names: N. displodere, Nematocida displodere Luallen et al. 2016, Nematocida sp. JUm2807

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NEDG_00136	NEDG_00229	A0A177EJL3	A0A177EIF9	t-SNARE coiled-coil homology domain-containing protein.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.793
NEDG_00136	NEDG_00414	A0A177EJL3	A0A177ELT1	t-SNARE coiled-coil homology domain-containing protein.	GTP-binding protein SAR1; Belongs to the small GTPase superfamily. Arf family.	0.635
NEDG_00136	NEDG_00759	A0A177EJL3	A0A177ED22	t-SNARE coiled-coil homology domain-containing protein.	Protein transport protein SEC24.	0.679
NEDG_00136	NEDG_00777	A0A177EJL3	A0A177ECG6	t-SNARE coiled-coil homology domain-containing protein.	Protein transport protein SEC24.	0.724
NEDG_00136	NEDG_00811	A0A177EJL3	A0A177ECX6	t-SNARE coiled-coil homology domain-containing protein.	Protein transport protein SEC13; Belongs to the WD repeat SEC13 family.	0.699
NEDG_00136	NEDG_00843	A0A177EJL3	A0A177EE69	t-SNARE coiled-coil homology domain-containing protein.	Vesicle transport protein SEC22.	0.998
NEDG_00136	NEDG_01433	A0A177EJL3	A0A177EDU6	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein.	0.720
NEDG_00136	NEDG_01672	A0A177EJL3	A0A177EJU7	t-SNARE coiled-coil homology domain-containing protein.	Synaptobrevin-like YKT6.	0.999
NEDG_00136	NEDG_01746	A0A177EJL3	A0A177EDX2	t-SNARE coiled-coil homology domain-containing protein.	Protein transport protein SEC31.	0.656
NEDG_00136	NEDG_02050	A0A177EJL3	A0A177EMT2	t-SNARE coiled-coil homology domain-containing protein.	Uncharacterized protein.	0.999
NEDG_00229	NEDG_00136	A0A177EIF9	A0A177EJL3	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	t-SNARE coiled-coil homology domain-containing protein.	0.793
NEDG_00229	NEDG_00414	A0A177EIF9	A0A177ELT1	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	GTP-binding protein SAR1; Belongs to the small GTPase superfamily. Arf family.	0.965
NEDG_00229	NEDG_00759	A0A177EIF9	A0A177ED22	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC24.	0.999
NEDG_00229	NEDG_00777	A0A177EIF9	A0A177ECG6	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC24.	0.999
NEDG_00229	NEDG_00811	A0A177EIF9	A0A177ECX6	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC13; Belongs to the WD repeat SEC13 family.	0.988
NEDG_00229	NEDG_00843	A0A177EIF9	A0A177EE69	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Vesicle transport protein SEC22.	0.999
NEDG_00229	NEDG_01433	A0A177EIF9	A0A177EDU6	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.734
NEDG_00229	NEDG_01672	A0A177EIF9	A0A177EJU7	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Synaptobrevin-like YKT6.	0.787
NEDG_00229	NEDG_01746	A0A177EIF9	A0A177EDX2	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Protein transport protein SEC31.	0.989
NEDG_00229	NEDG_02050	A0A177EIF9	A0A177EMT2	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.800

page 1 of 6

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.216

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007021

Tubulin complex assembly

4 of 9

2.43

2.66

8.92e-06

GO:0015976

Carbon utilization

3 of 6

2.49

1.81

0.00044

GO:0071244

Cellular response to carbon dioxide

2 of 2

2.79

1.06

0.0119

GO:0007023

Post-chaperonin tubulin folding pathway

2 of 3

2.61

1.03

0.0132

GO:0006457

Protein folding

4 of 88

1.44

0.89

0.0109

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004089

Carbonate dehydratase activity

3 of 5

2.56

1.95

0.00025

GO:0015631

Tubulin binding

4 of 37

1.82

1.7

0.00026

GO:0048487

Beta-tubulin binding

2 of 2

2.79

1.2

0.0066

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005874

Microtubule

4 of 35

1.84

1.75

0.00021

GO:0015630

Microtubule cytoskeleton

5 of 94

1.51

1.5

0.00021

GO:0099080

Supramolecular complex

5 of 117

1.42

1.41

0.00021

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9794

Tubulin complex assembly, and Alpha-tubulin binding

6 of 10

2.56

5.36

3.12e-11

CL:9799

Beta-tubulin binding, and CAP Gly-rich domain

5 of 5

2.79

4.97

4.45e-10

CL:5291

Mixed, incl. Carbonate dehydratase activity, and Atypical dual-specificity phosphatase Siw14-like

3 of 26

1.85

1.25

0.0032

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00910

Nitrogen metabolism

3 of 12

2.18

1.91

0.00020

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-391251

Protein folding

4 of 24

2.01

2.05

6.85e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036874

Carbonic anhydrase superfamily

2 of 2

2.79

0.82

0.0332

IPR001765

Carbonic anhydrase

2 of 2

2.79

0.82

0.0332

IPR036859

CAP Gly-rich domain superfamily

2 of 4

2.49

0.81

0.0332

IPR000938

CAP Gly-rich domain

2 of 4

2.49

0.81

0.0332

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00947

Carbonic anhydrase

2 of 2

2.79

1.34

0.0037

SM01052

Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including ...

2 of 4

2.49

1.27

0.0046

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (14%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About