node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHFR-TS | DHFR-TS-2 | A0A4D8ZNA8 | A0A4D9C275 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.999 |
DHFR-TS | GGH | A0A4D8ZNA8 | A0A4D8Z985 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Folate gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS | GGH-2 | A0A4D8ZNA8 | A0A4D8ZSL9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Folate gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS | GGH-3 | A0A4D8ZNA8 | A0A4D9B358 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS | MTHFD | A0A4D8ZNA8 | A0A4D9AB77 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+). | 0.974 |
DHFR-TS | folB | A0A4D8ZNA8 | A0A4D8ZW09 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.605 |
DHFR-TS | folB-2 | A0A4D8ZNA8 | A0A4D9AQ19 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.605 |
DHFR-TS | folP-2 | A0A4D8ZNA8 | A0A4D8ZQ89 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.971 |
DHFR-TS | folP-4 | A0A4D8ZNA8 | A0A4D9BN76 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.971 |
DHFR-TS | folP-5 | A0A4D8ZNA8 | A0A4D9BQ81 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.933 |
DHFR-TS-2 | DHFR-TS | A0A4D9C275 | A0A4D8ZNA8 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.999 |
DHFR-TS-2 | GGH | A0A4D9C275 | A0A4D8Z985 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Folate gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS-2 | GGH-2 | A0A4D9C275 | A0A4D8ZSL9 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Folate gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS-2 | GGH-3 | A0A4D9C275 | A0A4D9B358 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Gamma-glutamyl hydrolase. | 0.936 |
DHFR-TS-2 | MTHFD | A0A4D9C275 | A0A4D9AB77 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Methylenetetrahydrofolate dehydrogenase (NADP+). | 0.974 |
DHFR-TS-2 | folB | A0A4D9C275 | A0A4D8ZW09 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.605 |
DHFR-TS-2 | folB-2 | A0A4D9C275 | A0A4D9AQ19 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.605 |
DHFR-TS-2 | folP-2 | A0A4D9C275 | A0A4D8ZQ89 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.971 |
DHFR-TS-2 | folP-4 | A0A4D9C275 | A0A4D9BN76 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.971 |
DHFR-TS-2 | folP-5 | A0A4D9C275 | A0A4D9BQ81 | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | Dihydropteroate synthase. | 0.933 |