ENSSFAP00005029594 protein (Salarias fasciatus)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

ENSSFAP00005029594

Si:dkey-34e4.1. (260 aa)

Predicted Functional Partners:

ENSSFAP00005031956

0.935

ENSSFAP00005039071

0.935

ENSSFAP00005053089

0.935

ndor1

0.931

dtnb

0.883

ENSSFAP00005038963

0.883

LOC115401767

0.883

LOC115387299

0.878

rasd1

0.878

LOC115391527

0.877

Your Current Organism:

Salarias fasciatus

NCBI taxonomy Id: 181472
Other names: S. fasciatus, jewelled blenny

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSFAP00005029594	ENSSFAP00005031956	ENSSFAP00005029594	ENSSFAP00005031956	Si:dkey-34e4.1.	P450 (cytochrome) oxidoreductase b.	0.935
ENSSFAP00005029594	ENSSFAP00005038963	ENSSFAP00005029594	ENSSFAP00005038963	Si:dkey-34e4.1.	Dystrobrevin, alpha.	0.883
ENSSFAP00005029594	ENSSFAP00005039071	ENSSFAP00005029594	ENSSFAP00005039071	Si:dkey-34e4.1.	Nitric oxide synthase 1 (neuronal).	0.935
ENSSFAP00005029594	ENSSFAP00005053089	ENSSFAP00005029594	ENSSFAP00005053089	Si:dkey-34e4.1.	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	0.935
ENSSFAP00005029594	LOC115387299	ENSSFAP00005029594	ENSSFAP00005013175	Si:dkey-34e4.1.	Dexamethasone-induced Ras-related protein 1-like.	0.878
ENSSFAP00005029594	LOC115391527	ENSSFAP00005029594	ENSSFAP00005003651	Si:dkey-34e4.1.	Beta-2-syntrophin-like.	0.877
ENSSFAP00005029594	LOC115401767	ENSSFAP00005029594	ENSSFAP00005043191	Si:dkey-34e4.1.	Dystrobrevin beta-like.	0.883
ENSSFAP00005029594	dtnb	ENSSFAP00005029594	ENSSFAP00005037047	Si:dkey-34e4.1.	Dystrobrevin beta.	0.883
ENSSFAP00005029594	ndor1	ENSSFAP00005029594	ENSSFAP00005008127	Si:dkey-34e4.1.	NADPH dependent diflavin oxidoreductase 1.	0.931
ENSSFAP00005029594	rasd1	ENSSFAP00005029594	ENSSFAP00005042112	Si:dkey-34e4.1.	Ras related dexamethasone induced 1.	0.878
ENSSFAP00005031956	ENSSFAP00005029594	ENSSFAP00005031956	ENSSFAP00005029594	P450 (cytochrome) oxidoreductase b.	Si:dkey-34e4.1.	0.935
ENSSFAP00005031956	LOC115387299	ENSSFAP00005031956	ENSSFAP00005013175	P450 (cytochrome) oxidoreductase b.	Dexamethasone-induced Ras-related protein 1-like.	0.472
ENSSFAP00005031956	LOC115391527	ENSSFAP00005031956	ENSSFAP00005003651	P450 (cytochrome) oxidoreductase b.	Beta-2-syntrophin-like.	0.532
ENSSFAP00005031956	rasd1	ENSSFAP00005031956	ENSSFAP00005042112	P450 (cytochrome) oxidoreductase b.	Ras related dexamethasone induced 1.	0.472
ENSSFAP00005038963	ENSSFAP00005029594	ENSSFAP00005038963	ENSSFAP00005029594	Dystrobrevin, alpha.	Si:dkey-34e4.1.	0.883
ENSSFAP00005038963	LOC115391527	ENSSFAP00005038963	ENSSFAP00005003651	Dystrobrevin, alpha.	Beta-2-syntrophin-like.	0.797
ENSSFAP00005039071	ENSSFAP00005029594	ENSSFAP00005039071	ENSSFAP00005029594	Nitric oxide synthase 1 (neuronal).	Si:dkey-34e4.1.	0.935
ENSSFAP00005039071	LOC115387299	ENSSFAP00005039071	ENSSFAP00005013175	Nitric oxide synthase 1 (neuronal).	Dexamethasone-induced Ras-related protein 1-like.	0.878
ENSSFAP00005039071	LOC115391527	ENSSFAP00005039071	ENSSFAP00005003651	Nitric oxide synthase 1 (neuronal).	Beta-2-syntrophin-like.	0.667
ENSSFAP00005039071	rasd1	ENSSFAP00005039071	ENSSFAP00005042112	Nitric oxide synthase 1 (neuronal).	Ras related dexamethasone induced 1.	0.878

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.866

expected number of edges:

10

PPI enrichment p-value:

0.000427

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 271

1.05

1.36

3.63e-09

GO:0015833

Peptide transport

2 of 4

2.14

0.81

0.0315

GO:0055085

Transmembrane transport

6 of 195

0.93

0.66

0.0070

GO:0071702

Organic substance transport

4 of 79

1.15

0.62

0.0310

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904680

Peptide transmembrane transporter activity

2 of 5

2.05

0.76

0.0378

GO:0005524

ATP binding

7 of 359

0.73

0.43

0.0378

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

2 of 5

2.05

1.13

0.0071

GO:0005886

Plasma membrane

11 of 374

0.91

1.06

1.26e-08

GO:0043190

ATP-binding cassette (ABC) transporter complex

2 of 8

1.84

0.98

0.0120

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3855

Solute-binding protein family 5, and Oligopeptide/dipeptide ABC transporter, C-terminal

6 of 6

2.44

4.82

2.45e-10

CL:3753

Mixed, incl. ABC transporters, and FtsX-like permease family

9 of 80

1.49

2.67

2.45e-10

CL:3755

Mixed, incl. ABC transporter-like, ATP-binding domain, and FtsX-like permease family

8 of 65

1.53

2.63

2.42e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ctm02024

Quorum sensing

7 of 34

1.76

3.27

1.55e-09

ctm02010

ABC transporters

3 of 41

1.31

0.72

0.0229

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 36

1.49

1.54

0.00012

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 60

1.27

1.18

0.00041

MAP-5663205

Infectious disease

4 of 65

1.23

1.15

0.00041

MAP-1643685

Disease

4 of 66

1.23

1.14

0.00041

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

7 of 233

0.92

0.78

0.00082

KW-0813

Transport

4 of 78

1.15

0.78

0.0089

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00496

Bacterial extracellular solute-binding proteins, family 5 Middle

2 of 2

2.44

0.83

0.0310

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003439

ABC transporter-like, ATP-binding domain

7 of 35

1.74

2.95

2.11e-08

IPR017871

ABC transporter-like, conserved site

6 of 27

1.79

2.72

2.66e-07

IPR003593

AAA+ ATPase domain

7 of 82

1.37

1.79

1.70e-06

IPR039424

Solute-binding protein family 5

2 of 2

2.44

0.96

0.0173

IPR030678

Peptide/nickel binding protein, MppA-type

2 of 2

2.44

0.96

0.0173

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

7 of 79

1.39

1.94

3.23e-07

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