naa40 protein (Salarias fasciatus) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

naa40

N(alpha)-acetyltransferase 40, NatD catalytic subunit. (239 aa)

Predicted Functional Partners:

wdr11

0.867

ENSSFAP00005006406

0.683

rpl35

0.583

naa30

0.582

ENSSFAP00005005284

0.573

naa50

0.572

naa10

0.570

naa60

0.563

naa25

0.561

ENSSFAP00005021371

0.555

Your Current Organism:

Salarias fasciatus

NCBI taxonomy Id: 181472
Other names: S. fasciatus, jewelled blenny

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSFAP00005005284	ENSSFAP00005021371	ENSSFAP00005005284	ENSSFAP00005021371	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 80, NatH catalytic subunit.	0.456
ENSSFAP00005005284	naa10	ENSSFAP00005005284	ENSSFAP00005043904	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	0.953
ENSSFAP00005005284	naa25	ENSSFAP00005005284	ENSSFAP00005046297	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 25, NatB auxiliary subunit.	0.999
ENSSFAP00005005284	naa30	ENSSFAP00005005284	ENSSFAP00005053761	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	0.965
ENSSFAP00005005284	naa40	ENSSFAP00005005284	ENSSFAP00005055049	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 40, NatD catalytic subunit.	0.573
ENSSFAP00005005284	naa50	ENSSFAP00005005284	ENSSFAP00005015249	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 50, NatE catalytic subunit.	0.965
ENSSFAP00005005284	naa60	ENSSFAP00005005284	ENSSFAP00005014289	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	N(alpha)-acetyltransferase 60, NatF catalytic subunit.	0.933
ENSSFAP00005005284	rpl35	ENSSFAP00005005284	ENSSFAP00005029880	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	Ribosomal protein L35.	0.512
ENSSFAP00005006406	naa40	ENSSFAP00005006406	ENSSFAP00005055049	Exportin, tRNA (nuclear export receptor for tRNAs).	N(alpha)-acetyltransferase 40, NatD catalytic subunit.	0.683
ENSSFAP00005006406	wdr11	ENSSFAP00005006406	ENSSFAP00005022830	Exportin, tRNA (nuclear export receptor for tRNAs).	WD repeat domain 11.	0.572
ENSSFAP00005021371	ENSSFAP00005005284	ENSSFAP00005021371	ENSSFAP00005005284	N(alpha)-acetyltransferase 80, NatH catalytic subunit.	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	0.456
ENSSFAP00005021371	naa40	ENSSFAP00005021371	ENSSFAP00005055049	N(alpha)-acetyltransferase 80, NatH catalytic subunit.	N(alpha)-acetyltransferase 40, NatD catalytic subunit.	0.555
ENSSFAP00005021371	naa60	ENSSFAP00005021371	ENSSFAP00005014289	N(alpha)-acetyltransferase 80, NatH catalytic subunit.	N(alpha)-acetyltransferase 60, NatF catalytic subunit.	0.544
naa10	ENSSFAP00005005284	ENSSFAP00005043904	ENSSFAP00005005284	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 20, NatB catalytic subunit.	0.953
naa10	naa25	ENSSFAP00005043904	ENSSFAP00005046297	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 25, NatB auxiliary subunit.	0.964
naa10	naa30	ENSSFAP00005043904	ENSSFAP00005053761	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 30, NatC catalytic subunit.	0.965
naa10	naa40	ENSSFAP00005043904	ENSSFAP00005055049	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 40, NatD catalytic subunit.	0.570
naa10	naa50	ENSSFAP00005043904	ENSSFAP00005015249	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 50, NatE catalytic subunit.	0.999
naa10	naa60	ENSSFAP00005043904	ENSSFAP00005014289	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	N(alpha)-acetyltransferase 60, NatF catalytic subunit.	0.983
naa10	rpl35	ENSSFAP00005043904	ENSSFAP00005029880	N(alpha)-acetyltransferase 10, NatA catalytic subunit.	Ribosomal protein L35.	0.805

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.844

expected number of edges:

11

PPI enrichment p-value:

0.0136

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048002

Antigen processing and presentation of peptide antigen

3 of 33

2.32

1.31

0.0036

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003823

Antigen binding

4 of 144

1.8

1.45

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7542

Mixed, incl. Calreticulin family, and ABC-type peptide transporter activity

4 of 12

2.88

3.7

1.49e-07

CL:31920

Mixed, incl. MHC protein complex binding, and Class I Histocompatibility antigen, domains alpha 1 and 2

5 of 55

2.32

3.44

1.49e-07

CL:31983

ER-Phagosome pathway, and Immunoglobulin V-set domain

3 of 21

2.51

2.38

3.48e-05

CL:7544

ABC-type peptide transporter activity, and Calreticulin family

2 of 5

2.96

1.67

0.00096

CL:31928

MHC class II protein complex, and Class II histocompatibility antigen, alpha domain

2 of 13

2.55

1.28

0.0045

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05168

Herpes simplex virus 1 infection

5 of 466

1.39

0.00019

map04514

Cell adhesion molecules

4 of 366

1.4

1.16

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983170

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

5 of 79

2.16

3.31

1.40e-07

MAP-1280218

Adaptive Immune System

11 of 1468

1.23

1.94

4.71e-11

MAP-3000480

Scavenging by Class A Receptors

2 of 12

2.58

1.25

0.0053

MAP-198933

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

3 of 131

1.72

1.07

0.0066

MAP-983169

Class I MHC mediated antigen processing & presentation

5 of 693

1.22

0.95

0.0027

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042824

MHC class I peptide loading complex

2 of 9

2.71

1.01

0.0147

GOCC:0030665

Clathrin-coated vesicle membrane

2 of 42

2.04

0.75

0.0405

GOCC:0030118

Clathrin coat

2 of 39

2.07

0.75

0.0405

GOCC:0042571

Immunoglobulin complex, circulating

3 of 166

1.62

0.73

0.0344

GOCC:0005788

Endoplasmic reticulum lumen

2 of 58

1.9

0.7

0.0475

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

2 of 33

2.14

0.93

0.0183

KW-0732

Signal

8 of 3044

0.78

0.61

0.0020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00262

Calreticulin family

2 of 6

2.88

1.07

0.0118

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00809

Adaptin C-terminal domain

2 of 11

2.62

1.08

0.0107

SM00409

Immunoglobulin

4 of 536

1.23

0.69

0.0244

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