jak3 protein (Salarias fasciatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

jak3

Janus kinase 3. (1119 aa)

Predicted Functional Partners:

LOC115408430

0.938

LOC115388590

0.937

ENSSFAP00005029866

0.936

stat1

0.931

LOC115393448

0.926

LOC115387792

0.926

LOC115403115

0.924

ENSSFAP00005009485

0.920

ENSSFAP00005009515

0.920

LOC115403830

0.891

Your Current Organism:

Salarias fasciatus

NCBI taxonomy Id: 181472
Other names: S. fasciatus, jewelled blenny

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSFAP00005009485	LOC115387792	ENSSFAP00005009485	ENSSFAP00005029681	Signal transducer and activator of transcription 4.	Signal transducer and activator of transcription 5B-like.	0.644
ENSSFAP00005009485	LOC115393448	ENSSFAP00005009485	ENSSFAP00005021895	Signal transducer and activator of transcription 4.	Signal transducer and activator of transcription 5B-like.	0.644
ENSSFAP00005009485	LOC115403115	ENSSFAP00005009485	ENSSFAP00005033248	Signal transducer and activator of transcription 4.	Interferon alpha/beta receptor 1b-like.	0.867
ENSSFAP00005009485	LOC115403830	ENSSFAP00005009485	ENSSFAP00005009505	Signal transducer and activator of transcription 4.	Signal transducer and activator of transcription 1-alpha/beta-like.	0.650
ENSSFAP00005009485	LOC115408430	ENSSFAP00005009485	ENSSFAP00005049093	Signal transducer and activator of transcription 4.	Signal transducer and activator of transcription 6-like.	0.678
ENSSFAP00005009485	jak3	ENSSFAP00005009485	ENSSFAP00005056500	Signal transducer and activator of transcription 4.	Janus kinase 3.	0.920
ENSSFAP00005009515	LOC115387792	ENSSFAP00005009515	ENSSFAP00005029681	annotation not available	Signal transducer and activator of transcription 5B-like.	0.655
ENSSFAP00005009515	LOC115393448	ENSSFAP00005009515	ENSSFAP00005021895	annotation not available	Signal transducer and activator of transcription 5B-like.	0.657
ENSSFAP00005009515	LOC115403115	ENSSFAP00005009515	ENSSFAP00005033248	annotation not available	Interferon alpha/beta receptor 1b-like.	0.867
ENSSFAP00005009515	LOC115403830	ENSSFAP00005009515	ENSSFAP00005009505	annotation not available	Signal transducer and activator of transcription 1-alpha/beta-like.	0.646
ENSSFAP00005009515	LOC115408430	ENSSFAP00005009515	ENSSFAP00005049093	annotation not available	Signal transducer and activator of transcription 6-like.	0.672
ENSSFAP00005009515	jak3	ENSSFAP00005009515	ENSSFAP00005056500	annotation not available	Janus kinase 3.	0.920
ENSSFAP00005029866	LOC115387792	ENSSFAP00005029866	ENSSFAP00005029681	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 5B-like.	0.779
ENSSFAP00005029866	LOC115388590	ENSSFAP00005029866	ENSSFAP00005054591	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 1-alpha/beta-like.	0.410
ENSSFAP00005029866	LOC115393448	ENSSFAP00005029866	ENSSFAP00005021895	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 5B-like.	0.779
ENSSFAP00005029866	LOC115403115	ENSSFAP00005029866	ENSSFAP00005033248	Signal transducer and activator of transcription 3 (acute-phase response factor).	Interferon alpha/beta receptor 1b-like.	0.867
ENSSFAP00005029866	LOC115403830	ENSSFAP00005029866	ENSSFAP00005009505	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 1-alpha/beta-like.	0.645
ENSSFAP00005029866	LOC115408430	ENSSFAP00005029866	ENSSFAP00005049093	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 6-like.	0.860
ENSSFAP00005029866	jak3	ENSSFAP00005029866	ENSSFAP00005056500	Signal transducer and activator of transcription 3 (acute-phase response factor).	Janus kinase 3.	0.936
ENSSFAP00005029866	stat1	ENSSFAP00005029866	ENSSFAP00005042732	Signal transducer and activator of transcription 3 (acute-phase response factor).	Signal transducer and activator of transcription 1.	0.646

page 1 of 5

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.8

expected number of edges:

7

PPI enrichment p-value:

0.476

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

3 of 9

2.06

1.21

0.0048

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

4 of 20

1.84

1.7

0.00027

GO:0016668

Oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

3 of 9

2.06

1.47

0.0014

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 2

2.54

1.15

0.0080

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.45

0.76

0.0236

GO:0016491

Oxidoreductase activity

7 of 292

0.92

0.75

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:701

Thioredoxin domain, and Cellular response to oxidative stress

5 of 11

2.2

3.25

2.41e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00380

Tryptophan metabolism

2 of 9

1.89

0.83

0.0254

map00310

Lysine degradation

2 of 9

1.89

0.83

0.0254

map00630

Glyoxylate and dicarboxylate metabolism

3 of 39

1.42

0.75

0.0239

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

4 of 11

2.1

2.44

1.16e-05

KW-0274

FAD

3 of 25

1.62

1.11

0.0043

KW-0560

Oxidoreductase

6 of 166

1.1

1.01

0.00034

KW-0520

NAD

3 of 41

1.4

0.88

0.0103

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 4

2.41

1.86

0.00033

PF00578

AhpC/TSA family

3 of 8

2.11

1.61

0.00078

PF13738

Pyridine nucleotide-disulphide oxidoreductase

2 of 3

2.36

1.02

0.0135

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036249

Thioredoxin-like superfamily

5 of 27

1.81

2.12

1.97e-05

IPR013766

Thioredoxin domain

4 of 13

2.03

2.07

6.44e-05

IPR012999

Pyridine nucleotide-disulphide oxidoreductase, class I, active site

3 of 3

2.54

2.03

0.00017

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

3 of 3

2.54

2.03

0.00017

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.41

2.0

0.00018

(more ...)

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