OGE74073.1 protein (Doudnabacteria bacterium RIFCSPHIGHO201FULL4186)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

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Score

OGE74073.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (105 aa)

Predicted Functional Partners:

OGE74074.1

0.773

OGE74075.1

0.773

OGE74076.1

0.655

OGE74077.1

0.655

OGE74072.1

0.550

OGE74078.1

0.449

Your Current Organism:

Doudnabacteria bacterium RIFCSPHIGHO201FULL4186

NCBI taxonomy Id: 1817821
Other names: C. Doudnabacteria bacterium RIFCSPHIGHO2_01_FULL_41_86, Candidatus Doudnabacteria bacterium RIFCSPHIGHO2_01_FULL_41_86

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGE74072.1	OGE74073.1	A2717_00885	A2717_00890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.550
OGE74072.1	OGE74074.1	A2717_00885	A2717_00895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.675
OGE74072.1	OGE74075.1	A2717_00885	A2717_00900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.550
OGE74072.1	OGE74076.1	A2717_00885	A2717_00905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.472
OGE74072.1	OGE74077.1	A2717_00885	A2717_00910	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.476
OGE74073.1	OGE74072.1	A2717_00890	A2717_00885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.550
OGE74073.1	OGE74074.1	A2717_00890	A2717_00895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OGE74073.1	OGE74075.1	A2717_00890	A2717_00900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGE74073.1	OGE74076.1	A2717_00890	A2717_00905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.655
OGE74073.1	OGE74077.1	A2717_00890	A2717_00910	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.655
OGE74073.1	OGE74078.1	A2717_00890	A2717_00915	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.449
OGE74074.1	OGE74072.1	A2717_00895	A2717_00885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.675
OGE74074.1	OGE74073.1	A2717_00895	A2717_00890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGE74074.1	OGE74075.1	A2717_00895	A2717_00900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGE74074.1	OGE74076.1	A2717_00895	A2717_00905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.655
OGE74074.1	OGE74077.1	A2717_00895	A2717_00910	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.767
OGE74074.1	OGE74078.1	A2717_00895	A2717_00915	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.449
OGE74075.1	OGE74072.1	A2717_00900	A2717_00885	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.550
OGE74075.1	OGE74073.1	A2717_00900	A2717_00890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
OGE74075.1	OGE74074.1	A2717_00900	A2717_00895	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.764

expected number of edges:

12

PPI enrichment p-value:

2.26e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043137

DNA replication, removal of RNA primer

6 of 10

3.01

6.88

1.46e-13

GO:0006260

DNA replication

11 of 207

1.95

6.0

2.02e-18

GO:0000727

Double-strand break repair via break-induced replication

6 of 21

2.68

5.99

2.69e-12

GO:0006267

Pre-replicative complex assembly involved in nuclear cell cycle DNA replication

4 of 13

2.72

3.89

5.10e-08

GO:0030174

Regulation of DNA-templated DNA replication initiation

4 of 15

2.65

3.81

6.46e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003887

DNA-directed DNA polymerase activity

5 of 36

2.37

3.86

2.18e-08

GO:0003688

DNA replication origin binding

4 of 35

2.29

2.89

2.11e-06

GO:0140097

Catalytic activity, acting on DNA

7 of 271

1.64

2.69

2.85e-08

GO:0140640

Catalytic activity, acting on a nucleic acid

11 of 761

1.39

2.55

1.38e-12

GO:0004536

Deoxyribonuclease activity

3 of 46

2.04

1.6

0.00073

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043596

Nuclear replication fork

9 of 60

2.4

7.92

4.29e-18

GO:0032993

protein-DNA complex

9 of 88

2.24

7.0

3.59e-17

GO:0043625

Delta DNA polymerase complex

5 of 8

3.02

6.08

5.42e-12

GO:0042555

MCM complex

4 of 11

2.79

4.41

5.72e-09

GO:0071162

CMG complex

4 of 13

2.72

4.26

9.38e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15562

Delta DNA polymerase complex

5 of 8

3.02

5.41

1.01e-10

CL:15466

Polymerase switching, and Epsilon DNA polymerase complex

6 of 56

2.26

4.37

7.70e-10

CL:15317

Mixed, incl. Lagging Strand Synthesis, and Homology Directed Repair

7 of 141

1.92

3.75

7.70e-10

CL:15683

Pre-replicative complex, and Mitotic DNA replication preinitiation complex assembly

4 of 26

2.42

3.16

8.12e-07

CL:15720

MCM domain

2 of 5

2.83

1.5

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

11 of 112

2.22

8.56

1.04e-22

map03410

Base excision repair

7 of 70

2.23

5.58

3.99e-13

map03440

Homologous recombination

5 of 82

2.01

3.32

4.67e-08

map03430

Mismatch repair

5 of 94

1.95

3.17

6.76e-08

map03420

Nucleotide excision repair

5 of 116

1.86

2.91

1.49e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-69239

Synthesis of DNA

11 of 113

2.22

8.3

7.32e-22

MAP-69242

S Phase

11 of 120

2.19

8.15

7.32e-22

MAP-69306

DNA Replication

11 of 137

2.13

7.71

1.84e-21

MAP-69166

Removal of the Flap Intermediate

7 of 37

2.5

6.77

1.37e-14

MAP-69183

Processive synthesis on the lagging strand

7 of 41

2.46

6.6

2.25e-14

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043625

Delta DNA polymerase complex

5 of 13

2.81

5.09

2.74e-10

GOCC:0042555

MCM complex

4 of 9

2.88

4.27

1.22e-08

GOCC:0031981

Nuclear lumen

7 of 1072

1.04

1.03

7.50e-05

GOCC:0032991

Protein-containing complex

9 of 4391

0.54

0.4

0.0060

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

7 of 52

2.36

5.99

2.06e-13

KW-0347

Helicase

4 of 62

2.04

2.57

4.41e-06

KW-0238

DNA-binding

5 of 203

1.62

2.08

5.15e-06

KW-0539

Nucleus

7 of 568

1.32

1.72

1.09e-06

KW-0269

Exonuclease

2 of 9

2.57

1.68

0.00082

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12619

Mini-chromosome maintenance protein 2

2 of 2

3.23

1.26

0.0053

PF09507

DNA polymerase subunit Cdc27

2 of 2

3.23

1.26

0.0053

PF04042

DNA polymerase alpha/epsilon subunit B

2 of 6

2.75

1.15

0.0082

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041562

MCM, AAA-lid domain

4 of 11

2.79

3.34

6.70e-07

IPR033762

MCM OB domain

4 of 11

2.79

3.34

6.70e-07

IPR031327

Mini-chromosome maintenance protein

4 of 11

2.79

3.34

6.70e-07

IPR027925

MCM N-terminal domain

4 of 11

2.79

3.34

6.70e-07

IPR018525

Mini-chromosome maintenance, conserved site

4 of 11

2.79

3.34

6.70e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00350

Minichromosome maintenance proteins

4 of 8

2.93

4.19

1.84e-08

SM00279

Helix-hairpin-helix class 2 (Pol1 family) motifs

2 of 6

2.75

1.43

0.0025

SM00485

Xeroderma pigmentosum G N-region

2 of 8

2.63

1.41

0.0027

SM00484

Xeroderma pigmentosum G I-region

2 of 8

2.63

1.41

0.0027

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