STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OGL52457.15,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)    
Predicted Functional Partners:
OGL51293.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
OGL52456.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.988
OGL53524.1
Cystathionine gamma-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.933
OGL52454.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
 
 0.889
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.860
OGL52458.1
Peptide ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.
       0.773
OGL52641.1
FeS-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.755
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.749
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.703
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.697
Your Current Organism:
Schekmanbacteria bacterium RIFCSPLOWO212FULL3815
NCBI taxonomy Id: 1817883
Other names: C. Schekmanbacteria bacterium RIFCSPLOWO2_12_FULL_38_15, Candidatus Schekmanbacteria bacterium RIFCSPLOWO2_12_FULL_38_15
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