OGJ98803.1 protein (Raymondbacteria bacterium RIFOXYC2FULL5021)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

OGJ98803.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (465 aa)

Predicted Functional Partners:

OGJ98077.1

0.808

OGJ99091.1

0.803

OGJ96728.1

0.792

OGJ96003.1

0.790

OGJ98784.1

0.784

OGJ97036.1

0.779

OGJ97177.1

0.770

OGJ97058.1

0.762

OGJ95261.1

0.756

OGJ99216.1

0.756

Your Current Organism:

Raymondbacteria bacterium RIFOXYC2FULL5021

NCBI taxonomy Id: 1817889
Other names: C. Raymondbacteria bacterium RIFOXYC2_FULL_50_21, Candidatus Raymondbacteria bacterium RIFOXYC2_FULL_50_21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OGJ95261.1	OGJ98803.1	A2453_05700	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.756
OGJ96003.1	OGJ97036.1	A2453_05205	A2453_04095	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.615
OGJ96003.1	OGJ98077.1	A2453_05205	A2453_12315	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.843
OGJ96003.1	OGJ98784.1	A2453_05205	A2453_09875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.516
OGJ96003.1	OGJ98803.1	A2453_05205	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.790
OGJ96003.1	OGJ99091.1	A2453_05205	A2453_11170	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.621
OGJ96728.1	OGJ98077.1	A2453_06130	A2453_12315	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.605
OGJ96728.1	OGJ98803.1	A2453_06130	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.792
OGJ96728.1	OGJ99091.1	A2453_06130	A2453_11170	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.581
OGJ97036.1	OGJ96003.1	A2453_04095	A2453_05205	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.615
OGJ97036.1	OGJ97177.1	A2453_04095	A2453_10345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.544
OGJ97036.1	OGJ98077.1	A2453_04095	A2453_12315	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.831
OGJ97036.1	OGJ98803.1	A2453_04095	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.779
OGJ97036.1	OGJ99091.1	A2453_04095	A2453_11170	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.599
OGJ97058.1	OGJ98803.1	A2453_04210	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.762
OGJ97177.1	OGJ97036.1	A2453_10345	A2453_04095	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.544
OGJ97177.1	OGJ98077.1	A2453_10345	A2453_12315	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.845
OGJ97177.1	OGJ98784.1	A2453_10345	A2453_09875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.415
OGJ97177.1	OGJ98803.1	A2453_10345	A2453_09975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.770
OGJ97177.1	OGJ99091.1	A2453_10345	A2453_11170	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.623

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

13

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006090

Pyruvate metabolic process

5 of 26

1.78

2.08

2.13e-05

GO:0045454

Cell redox homeostasis

3 of 9

2.02

1.57

0.00084

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

2 of 2

2.5

1.37

0.0030

GO:0006096

Glycolytic process

3 of 18

1.72

1.22

0.0030

GO:0009150

Purine ribonucleotide metabolic process

5 of 79

1.3

1.15

0.00076

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

5 of 7

2.35

3.66

5.65e-08

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

4 of 6

2.32

2.79

3.70e-06

GO:0016417

S-acyltransferase activity

2 of 4

2.2

0.99

0.0147

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.41

0.77

0.0204

GO:0016491

Oxidoreductase activity

8 of 380

0.82

0.71

0.00036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1404

Pyruvate dehydrogenase activity, and e3 binding domain

9 of 13

2.34

7.17

1.15e-16

CL:1406

Pyruvate dehydrogenase activity, and Peptidyl-lysine modification

5 of 5

2.5

4.42

2.31e-09

CL:1367

Mixed, incl. Citrate cycle (TCA cycle), and Oxidoreduction-driven active transmembrane transporter activity

10 of 68

1.66

3.81

5.55e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mvd00020

Citrate cycle (TCA cycle)

7 of 33

1.82

3.53

6.31e-10

mvd00620

Pyruvate metabolism

6 of 54

1.54

2.23

3.78e-07

mvd00010

Glycolysis / Gluconeogenesis

6 of 56

1.53

2.2

3.78e-07

mvd01200

Carbon metabolism

8 of 123

1.31

1.9

3.18e-08

mvd01120

Microbial metabolism in diverse environments

9 of 342

0.92

0.99

1.17e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 17

1.97

2.85

5.77e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00676

Dehydrogenase E1 component

3 of 3

2.5

1.96

0.00023

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 3

2.32

0.9

0.0220

PF02780

Transketolase, C-terminal domain

2 of 4

2.2

0.89

0.0220

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 4

2.2

0.89

0.0220

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 5

2.1

0.89

0.0220

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 14

2.05

2.76

1.62e-06

IPR001017

Dehydrogenase, E1 component

3 of 3

2.5

1.9

0.00030

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.37

1.84

0.00035

IPR005475

Transketolase-like, pyrimidine-binding domain

3 of 6

2.2

1.67

0.00063

IPR023753

FAD/NAD(P)-binding domain

3 of 12

1.89

1.29

0.0027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 6

2.2

1.92

0.00020

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