CVT24_008866 protein (Panaeolus cyanescens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CVT24_008866

4HBT domain-containing protein. (295 aa)

Predicted Functional Partners:

CVT24_007564

0.820

CVT24_009701

0.815

CVT24_008248

0.711

CVT24_006056

0.612

CVT24_010545

0.482

CVT24_005746

0.470

CVT24_000523

0.470

CVT24_005789

0.470

CVT24_005662

0.470

CVT24_007863

0.470

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000523	CVT24_008866	A0A409VAI2	A0A409VAV4	Uncharacterized protein.	4HBT domain-containing protein.	0.470
CVT24_005662	CVT24_007564	A0A409VBQ7	A0A409VR73	Protein kinase domain-containing protein.	Uncharacterized protein.	0.513
CVT24_005662	CVT24_008866	A0A409VBQ7	A0A409VAV4	Protein kinase domain-containing protein.	4HBT domain-containing protein.	0.470
CVT24_005746	CVT24_008866	A0A409V963	A0A409VAV4	Protein kinase domain-containing protein.	4HBT domain-containing protein.	0.470
CVT24_005789	CVT24_008866	A0A409VB74	A0A409VAV4	TRP domain-containing protein.	4HBT domain-containing protein.	0.470
CVT24_006056	CVT24_008866	A0A409YDV1	A0A409VAV4	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	4HBT domain-containing protein.	0.612
CVT24_007564	CVT24_005662	A0A409VR73	A0A409VBQ7	Uncharacterized protein.	Protein kinase domain-containing protein.	0.513
CVT24_007564	CVT24_008866	A0A409VR73	A0A409VAV4	Uncharacterized protein.	4HBT domain-containing protein.	0.820
CVT24_007863	CVT24_008866	A0A409VEZ5	A0A409VAV4	RING-type domain-containing protein.	4HBT domain-containing protein.	0.470
CVT24_008248	CVT24_008866	A0A409VF75	A0A409VAV4	Uncharacterized protein.	4HBT domain-containing protein.	0.711
CVT24_008866	CVT24_000523	A0A409VAV4	A0A409VAI2	4HBT domain-containing protein.	Uncharacterized protein.	0.470
CVT24_008866	CVT24_005662	A0A409VAV4	A0A409VBQ7	4HBT domain-containing protein.	Protein kinase domain-containing protein.	0.470
CVT24_008866	CVT24_005746	A0A409VAV4	A0A409V963	4HBT domain-containing protein.	Protein kinase domain-containing protein.	0.470
CVT24_008866	CVT24_005789	A0A409VAV4	A0A409VB74	4HBT domain-containing protein.	TRP domain-containing protein.	0.470
CVT24_008866	CVT24_006056	A0A409VAV4	A0A409YDV1	4HBT domain-containing protein.	V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.612
CVT24_008866	CVT24_007564	A0A409VAV4	A0A409VR73	4HBT domain-containing protein.	Uncharacterized protein.	0.820
CVT24_008866	CVT24_007863	A0A409VAV4	A0A409VEZ5	4HBT domain-containing protein.	RING-type domain-containing protein.	0.470
CVT24_008866	CVT24_008248	A0A409VAV4	A0A409VF75	4HBT domain-containing protein.	Uncharacterized protein.	0.711
CVT24_008866	CVT24_009701	A0A409VAV4	A0A409Y9P2	4HBT domain-containing protein.	Uncharacterized protein.	0.815
CVT24_008866	CVT24_010545	A0A409VAV4	A0A409YYH7	4HBT domain-containing protein.	PUM-HD domain-containing protein.	0.482

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.228

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005102

Signaling receptor binding

8 of 779

1.61

2.78

4.59e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37709

Fibrinogen-related domains (FReDs), and Protein-glutamine gamma-glutamyltransferase, animal

6 of 52

2.66

5.64

1.27e-11

CL:37759

Transglutaminase-like superfamily, and Fibrinogen-related domains (FReDs)

4 of 20

2.9

4.11

2.51e-08

CL:2569

Integrin alpha beta-propellor, and Fibrinogen-related domains (FReDs)

3 of 25

2.68

2.44

3.15e-05

CL:37803

Transglutaminase family, and Fibrinogen-related domains (FReDs)

2 of 5

3.2

1.82

0.00052

CL:10996

Integrin cell surface interactions, and Calcium-binding EGF-like domain

2 of 8

2.99

1.66

0.0010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1566977

Fibronectin matrix formation

2 of 2

3.6

1.86

0.00046

MAP-3000170

Syndecan interactions

2 of 6

3.12

1.64

0.0011

MAP-372708

p130Cas linkage to MAPK signaling for integrins

2 of 18

2.64

1.32

0.0039

MAP-354194

GRB2:SOS provides linkage to MAPK signaling for Integrins

2 of 17

2.67

1.32

0.0039

MAP-3000178

ECM proteoglycans

2 of 20

2.6

1.32

0.0039

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

7 of 933

1.47

2.15

1.96e-07

KW-0732

Signal

7 of 4944

0.75

0.53

0.0080

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002181

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

8 of 111

2.45

6.92

3.53e-15

IPR014716

Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

8 of 112

2.45

6.91

3.53e-15

IPR036056

Fibrinogen-like, C-terminal

8 of 113

2.45

6.9

3.53e-15

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00186

Fibrinogen-related domains (FReDs)

8 of 109

2.46

7.39

2.63e-16

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Fusion

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About