CVT24_009565 protein (Panaeolus cyanescens) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

CVT24_009565

SGNH_hydro domain-containing protein. (257 aa)

Predicted Functional Partners:

CVT24_007151

0.983

CVT24_008817

0.677

CVT24_000510

0.651

CVT24_012053

0.646

CVT24_013175

0.641

CVT24_013176

0.641

CVT24_008918

0.623

CVT24_001492

0.618

CVT24_005240

0.605

CVT24_001053

0.587

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000510	CVT24_001492	A0A409V8E8	A0A409W339	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.750
CVT24_000510	CVT24_007151	A0A409V8E8	A0A409YPH7	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.780
CVT24_000510	CVT24_008817	A0A409V8E8	A0A409VKI0	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.476
CVT24_000510	CVT24_008918	A0A409V8E8	A0A409VAZ4	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	ANK_REP_REGION domain-containing protein.	0.709
CVT24_000510	CVT24_009565	A0A409V8E8	A0A409YAB0	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	SGNH_hydro domain-containing protein.	0.651
CVT24_000510	CVT24_013175	A0A409V8E8	A0A409VVY2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Glutamine amidotransferase type-1 domain-containing protein.	0.667
CVT24_000510	CVT24_013176	A0A409V8E8	A0A409VVY6	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Glutamine amidotransferase type-1 domain-containing protein.	0.667
CVT24_001053	CVT24_005240	A0A409VX62	A0A409Y9A0	Phos_pyr_kin domain-containing protein.	Uncharacterized protein.	0.903
CVT24_001053	CVT24_007151	A0A409VX62	A0A409YPH7	Phos_pyr_kin domain-containing protein.	Uncharacterized protein.	0.947
CVT24_001053	CVT24_009565	A0A409VX62	A0A409YAB0	Phos_pyr_kin domain-containing protein.	SGNH_hydro domain-containing protein.	0.587
CVT24_001053	CVT24_012053	A0A409VX62	A0A409VHY8	Phos_pyr_kin domain-containing protein.	Uncharacterized protein.	0.794
CVT24_001492	CVT24_000510	A0A409W339	A0A409V8E8	NADPH:adrenodoxin oxidoreductase, mitochondrial.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.750
CVT24_001492	CVT24_008918	A0A409W339	A0A409VAZ4	NADPH:adrenodoxin oxidoreductase, mitochondrial.	ANK_REP_REGION domain-containing protein.	0.749
CVT24_001492	CVT24_009565	A0A409W339	A0A409YAB0	NADPH:adrenodoxin oxidoreductase, mitochondrial.	SGNH_hydro domain-containing protein.	0.618
CVT24_005240	CVT24_001053	A0A409Y9A0	A0A409VX62	Uncharacterized protein.	Phos_pyr_kin domain-containing protein.	0.903
CVT24_005240	CVT24_009565	A0A409Y9A0	A0A409YAB0	Uncharacterized protein.	SGNH_hydro domain-containing protein.	0.605
CVT24_007151	CVT24_000510	A0A409YPH7	A0A409V8E8	Uncharacterized protein.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.780
CVT24_007151	CVT24_001053	A0A409YPH7	A0A409VX62	Uncharacterized protein.	Phos_pyr_kin domain-containing protein.	0.947
CVT24_007151	CVT24_008817	A0A409YPH7	A0A409VKI0	Uncharacterized protein.	Uncharacterized protein.	0.821
CVT24_007151	CVT24_008918	A0A409YPH7	A0A409VAZ4	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.709

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.934

expected number of edges:

35

PPI enrichment p-value:

0.0106

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

6 of 207

1.19

1.14

0.00026

GO:0018106

Peptidyl-histidine phosphorylation

4 of 104

1.31

0.98

0.0037

GO:0050794

Regulation of cellular process

9 of 641

0.87

0.8

0.00013

GO:0050896

Response to stimulus

7 of 541

0.84

0.66

0.0019

GO:0006796

Phosphate-containing compound metabolic process

5 of 376

0.85

0.5

0.0311

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

5 of 109

1.39

1.23

0.00077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3523

Mixed, incl. PAS-associated, C-terminal, and AAA ATPase domain

6 of 19

2.23

4.45

3.73e-10

CL:3520

PAS-associated, C-terminal, and GGDEF domain

7 of 30

2.1

4.44

8.77e-11

CL:3526

PAS-associated, C-terminal, and AAA ATPase domain

4 of 13

2.22

2.89

1.72e-06

CL:3527

PAS-associated, C-terminal, and AAA ATPase domain

3 of 7

2.36

2.23

5.66e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 575

0.92

0.96

4.76e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 110

1.39

1.43

0.00012

KW-0418

Kinase

6 of 161

1.3

1.42

4.12e-05

KW-0902

Two-component regulatory system

3 of 48

1.52

1.0

0.0067

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 72

1.65

2.17

3.67e-06

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 50

1.73

2.13

1.03e-05

IPR005467

Histidine kinase domain

6 of 80

1.6

2.1

3.67e-06

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 56

1.68

2.03

1.39e-05

IPR003594

Histidine kinase/HSP90-like ATPase

6 of 96

1.52

1.92

6.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

5 of 56

1.68

2.21

3.75e-06

SM00387

Histidine kinase-like ATPases

6 of 104

1.49

1.95

2.68e-06

SM00448

cheY-homologous receiver domain

5 of 101

1.42

1.59

4.10e-05

SM00073

Histidine Phosphotransfer domain

2 of 10

2.03

1.08

0.0087

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 18

1.77

0.87

0.0199

(more ...)

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