CVT24_002126 protein (Panaeolus cyanescens) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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Score

CVT24_002126

TFIID_20kDa domain-containing protein. (373 aa)

Predicted Functional Partners:

CVT24_000528

0.999

CVT24_006763

0.999

CVT24_005905

0.999

CVT24_008705

0.999

CVT24_009859

0.999

CVT24_005111

0.999

CVT24_003358

0.999

CVT24_011885

0.999

CVT24_003713

0.999

CVT24_002227

0.998

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000528	CVT24_002126	A0A409V8F9	A0A409YHZ0	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.999
CVT24_000528	CVT24_002227	A0A409V8F9	A0A409YIL5	Uncharacterized protein.	BTP domain-containing protein.	0.992
CVT24_000528	CVT24_003358	A0A409V8F9	A0A409Y723	Uncharacterized protein.	Uncharacterized protein.	0.999
CVT24_000528	CVT24_003713	A0A409V8F9	A0A409YXS5	Uncharacterized protein.	TAF domain-containing protein.	0.999
CVT24_000528	CVT24_005111	A0A409V8F9	A0A409W285	Uncharacterized protein.	Uncharacterized protein.	0.999
CVT24_000528	CVT24_005905	A0A409V8F9	A0A409VDJ2	Uncharacterized protein.	TAFII55_N domain-containing protein.	0.999
CVT24_000528	CVT24_006763	A0A409V8F9	A0A409V9F0	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.999
CVT24_000528	CVT24_008705	A0A409V8F9	A0A409VKI7	Uncharacterized protein.	Uncharacterized protein.	0.999
CVT24_000528	CVT24_009859	A0A409V8F9	A0A409VY21	Uncharacterized protein.	DUF3591 domain-containing protein.	0.999
CVT24_000528	CVT24_011885	A0A409V8F9	A0A409YNP3	Uncharacterized protein.	TAFII28 domain-containing protein.	0.999
CVT24_002126	CVT24_000528	A0A409YHZ0	A0A409V8F9	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.999
CVT24_002126	CVT24_002227	A0A409YHZ0	A0A409YIL5	TFIID_20kDa domain-containing protein.	BTP domain-containing protein.	0.998
CVT24_002126	CVT24_003358	A0A409YHZ0	A0A409Y723	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.999
CVT24_002126	CVT24_003713	A0A409YHZ0	A0A409YXS5	TFIID_20kDa domain-containing protein.	TAF domain-containing protein.	0.999
CVT24_002126	CVT24_005111	A0A409YHZ0	A0A409W285	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.999
CVT24_002126	CVT24_005905	A0A409YHZ0	A0A409VDJ2	TFIID_20kDa domain-containing protein.	TAFII55_N domain-containing protein.	0.999
CVT24_002126	CVT24_006763	A0A409YHZ0	A0A409V9F0	TFIID_20kDa domain-containing protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.999
CVT24_002126	CVT24_008705	A0A409YHZ0	A0A409VKI7	TFIID_20kDa domain-containing protein.	Uncharacterized protein.	0.999
CVT24_002126	CVT24_009859	A0A409YHZ0	A0A409VY21	TFIID_20kDa domain-containing protein.	DUF3591 domain-containing protein.	0.999
CVT24_002126	CVT24_011885	A0A409YHZ0	A0A409YNP3	TFIID_20kDa domain-containing protein.	TAFII28 domain-containing protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.856

expected number of edges:

14

PPI enrichment p-value:

2.87e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071840

Cellular component organization or biogenesis

10 of 1338

0.95

1.02

2.79e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016887

ATP hydrolysis activity

10 of 218

1.74

4.19

2.53e-14

GO:0016787

Hydrolase activity

11 of 1267

1.02

1.31

1.16e-09

GO:0005524

ATP binding

10 of 1174

1.01

1.22

4.95e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 4420

0.48

0.37

0.0039

GO:0043229

Intracellular organelle

11 of 5032

0.42

0.32

0.0081

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4198

Mixed, incl. Hedgehog ligand biogenesis, and Domain present in ubiquitin-regulatory proteins

10 of 54

2.35

8.35

6.26e-20

CL:4200

Hedgehog ligand biogenesis, and Derlin

7 of 28

2.48

6.43

6.63e-14

CL:4202

Mixed, incl. Sel1-like repeat, and Cellular response to topologically incorrect protein

4 of 23

2.32

2.98

1.52e-06

CL:4261

Mixed, incl. Ovarian tumor domain proteases, and PUL domain

3 of 15

2.38

2.12

9.72e-05

CL:4204

Mixed, incl. Sel1-like repeat, and Derlin

3 of 18

2.3

2.02

0.00014

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689896

Ovarian tumor domain proteases

10 of 17

2.85

11.95

1.64e-24

MAP-5358346

Hedgehog ligand biogenesis

10 of 32

2.57

10.24

1.43e-22

MAP-110320

Translesion Synthesis by POLH

10 of 33

2.56

10.19

1.43e-22

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

10 of 53

2.35

8.73

6.20e-21

MAP-73893

DNA Damage Bypass

10 of 58

2.32

8.46

1.13e-20

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008540

Proteasome regulatory particle, base subcomplex

2 of 3

2.9

1.44

0.0025

GOCC:0032991

Protein-containing complex

11 of 2435

0.73

0.7

6.95e-06

GOCC:0005737

Cytoplasm

9 of 2554

0.63

0.47

0.0039

GOCC:0005622

Intracellular

11 of 6178

0.33

0.25

0.0320

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003959

ATPase, AAA-type, core

10 of 66

2.26

7.62

7.71e-19

IPR003960

ATPase, AAA-type, conserved site

6 of 36

2.3

4.57

3.55e-10

IPR003593

AAA+ ATPase domain

9 of 155

1.84

4.35

4.96e-13

IPR041569

AAA ATPase, AAA+ lid domain

5 of 29

2.32

3.79

2.49e-08

IPR027417

P-loop containing nucleoside triphosphate hydrolase

10 of 686

1.24

1.86

1.33e-09

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

9 of 154

1.85

4.51

9.94e-14

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