node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HCW_00055 | HCW_00210 | HCW_00055 | HCW_00210 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.483 |
HCW_00055 | HCW_03195 | HCW_00055 | HCW_03195 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | ATPase AAA-2 domain-containing protein; COG0542 ATPases with chaperone activity, ATP-binding subunit. | 0.483 |
HCW_00055 | HCW_04945 | HCW_00055 | HCW_04945 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.671 |
HCW_00055 | clpP | HCW_00055 | HCW_05860 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.870 |
HCW_00055 | dnaK | HCW_00055 | HCW_00045 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.976 |
HCW_00055 | grpE | HCW_00055 | HCW_00050 | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.984 |
HCW_00210 | HCW_00055 | HCW_00210 | HCW_00055 | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | 0.483 |
HCW_00210 | clpP | HCW_00210 | HCW_05860 | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.882 |
HCW_00210 | dnaK | HCW_00210 | HCW_00045 | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.943 |
HCW_00210 | grpE | HCW_00210 | HCW_00050 | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.813 |
HCW_03195 | HCW_00055 | HCW_03195 | HCW_00055 | ATPase AAA-2 domain-containing protein; COG0542 ATPases with chaperone activity, ATP-binding subunit. | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | 0.483 |
HCW_03195 | clpP | HCW_03195 | HCW_05860 | ATPase AAA-2 domain-containing protein; COG0542 ATPases with chaperone activity, ATP-binding subunit. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.882 |
HCW_03195 | dnaK | HCW_03195 | HCW_00045 | ATPase AAA-2 domain-containing protein; COG0542 ATPases with chaperone activity, ATP-binding subunit. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.919 |
HCW_03195 | grpE | HCW_03195 | HCW_00050 | ATPase AAA-2 domain-containing protein; COG0542 ATPases with chaperone activity, ATP-binding subunit. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.738 |
HCW_04945 | HCW_00055 | HCW_04945 | HCW_00055 | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor; COG1420 Transcriptional regulator of heat shock gene. | 0.671 |
HCW_04945 | clpP | HCW_04945 | HCW_05860 | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.882 |
HCW_04945 | clpX | HCW_04945 | HCW_01085 | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.483 |
HCW_04945 | dnaK | HCW_04945 | HCW_00045 | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.946 |
HCW_04945 | grpE | HCW_04945 | HCW_00050 | ATP-dependent Clp protease, ATP-binding subunit ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.827 |
HCW_05850 | clpP | HCW_05850 | HCW_05860 | Sigma-54 interacting protein; COG0606 Predicted ATPase with chaperone activity. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.849 |