STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TlpAThiol-disulfide isomerase or thioredoxin. (218 aa)    
Predicted Functional Partners:
SFL53205.1
NUDIX domain-containing protein.
  
 0.971
nth
DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.935
resA
Thiol-disulfide isomerase or thioredoxin.
 
   
 0.851
msrA
Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 0.824
ahpC
Peroxiredoxin (alkyl hydroperoxide reductase subunit C).
  
 0.812
SFL53180.1
Colicin V production protein.
   
 
 0.798
SFL53286.1
Hypothetical protein.
     
 0.754
nrdE
Ribonucleoside-diphosphate reductase class Ib alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.676
MerA_3
Dihydrolipoamide dehydrogenase.
  
 0.640
MerA_2
Dihydrolipoamide dehydrogenase.
  
 0.640
Your Current Organism:
Nocardia asteroides
NCBI taxonomy Id: 1824
Other names: ATCC 19247, Actinomyces asteroides, Actinomyces eppinger, Actinomyces eppingeri, Asteroides asteroides, CCM 2754, CCUG 10073, CIP 104503, Cladothrix asteroides, DSM 43373, DSM 43757, Discomyces asteroides, IFO 15531, IMET 7547, JCM 3384, N. asteroides, NBRC 15531, NCTC 11293, NRRL B-3828, Oospora asteroides, Proactinomyces asteroides, Streptothrix eppingerii, Streptotrix asteroides
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