node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFL71861.1 | SFN46335.1 | SAMN05444423_101657 | SAMN05444423_109202 | Alanine-synthesizing transaminase. | Alanine-synthesizing transaminase. | 0.901 |
SFL71861.1 | ilvD-2 | SAMN05444423_101657 | SAMN05444423_10738 | Alanine-synthesizing transaminase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.921 |
SFL71861.1 | ilvE | SAMN05444423_101657 | SAMN05444423_11194 | Alanine-synthesizing transaminase. | Branched-chain amino acid aminotransferase. | 0.912 |
SFL71861.1 | leuA | SAMN05444423_101657 | SAMN05444423_10139 | Alanine-synthesizing transaminase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
SFL71861.1 | leuA-2 | SAMN05444423_101657 | SAMN05444423_102127 | Alanine-synthesizing transaminase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
SFN46335.1 | SFL71861.1 | SAMN05444423_109202 | SAMN05444423_101657 | Alanine-synthesizing transaminase. | Alanine-synthesizing transaminase. | 0.901 |
SFN46335.1 | ilvD-2 | SAMN05444423_109202 | SAMN05444423_10738 | Alanine-synthesizing transaminase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.921 |
SFN46335.1 | ilvE | SAMN05444423_109202 | SAMN05444423_11194 | Alanine-synthesizing transaminase. | Branched-chain amino acid aminotransferase. | 0.912 |
SFN46335.1 | leuA | SAMN05444423_109202 | SAMN05444423_10139 | Alanine-synthesizing transaminase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
SFN46335.1 | leuA-2 | SAMN05444423_109202 | SAMN05444423_102127 | Alanine-synthesizing transaminase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.909 |
ilvB-2 | ilvC | SAMN05444423_10736 | SAMN05444423_10734 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
ilvB-2 | ilvD-2 | SAMN05444423_10736 | SAMN05444423_10738 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.946 |
ilvB-2 | ilvE | SAMN05444423_10736 | SAMN05444423_11194 | Acetolactate synthase, large subunit. | Branched-chain amino acid aminotransferase. | 0.810 |
ilvB-2 | leuA | SAMN05444423_10736 | SAMN05444423_10139 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.924 |
ilvB-2 | leuA-2 | SAMN05444423_10736 | SAMN05444423_102127 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.924 |
ilvB-2 | leuC | SAMN05444423_10736 | SAMN05444423_106367 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.886 |
ilvB-2 | leuD | SAMN05444423_10736 | SAMN05444423_106366 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.892 |
ilvC | ilvB-2 | SAMN05444423_10734 | SAMN05444423_10736 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase, large subunit. | 0.999 |
ilvC | ilvD-2 | SAMN05444423_10734 | SAMN05444423_10738 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.998 |
ilvC | ilvE | SAMN05444423_10734 | SAMN05444423_11194 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Branched-chain amino acid aminotransferase. | 0.872 |