ANU55726.1 protein (Hungateiclostridiaceae bacterium KB18)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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[Homology]

Score

ANU55726.1

LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)

Predicted Functional Partners:

ANU55728.1

0.567

ANU55727.1

0.551

ANU55729.1

0.476

ANU55730.1

0.450

ANU55731.1

0.437

Your Current Organism:

Hungateiclostridiaceae bacterium KB18

NCBI taxonomy Id: 1834198
Other names: H. bacterium KB18, Ruminiclostridium sp. KB18

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANU55726.1	ANU55727.1	A4V00_17855	A4V00_17860	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
ANU55726.1	ANU55728.1	A4V00_17855	A4V00_17865	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.567
ANU55726.1	ANU55729.1	A4V00_17855	A4V00_17870	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
ANU55726.1	ANU55730.1	A4V00_17855	A4V00_17875	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	4Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.450
ANU55726.1	ANU55731.1	A4V00_17855	A4V00_17880	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.437
ANU55727.1	ANU55726.1	A4V00_17860	A4V00_17855	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.551
ANU55727.1	ANU55728.1	A4V00_17860	A4V00_17865	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.733
ANU55727.1	ANU55729.1	A4V00_17860	A4V00_17870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.660
ANU55727.1	ANU55730.1	A4V00_17860	A4V00_17875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	4Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.618
ANU55727.1	ANU55731.1	A4V00_17860	A4V00_17880	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.603
ANU55728.1	ANU55726.1	A4V00_17865	A4V00_17855	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.567
ANU55728.1	ANU55727.1	A4V00_17865	A4V00_17860	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.733
ANU55728.1	ANU55729.1	A4V00_17865	A4V00_17870	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
ANU55728.1	ANU55730.1	A4V00_17865	A4V00_17875	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	4Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664
ANU55728.1	ANU55731.1	A4V00_17865	A4V00_17880	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.642
ANU55729.1	ANU55726.1	A4V00_17870	A4V00_17855	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
ANU55729.1	ANU55727.1	A4V00_17870	A4V00_17860	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.660
ANU55729.1	ANU55728.1	A4V00_17870	A4V00_17865	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
ANU55729.1	ANU55730.1	A4V00_17870	A4V00_17875	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.727
ANU55729.1	ANU55731.1	A4V00_17870	A4V00_17880	Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.702

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.886

expected number of edges:

12

PPI enrichment p-value:

2.35e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

4 of 8

2.77

3.41

4.77e-07

GO:0031329

Regulation of cellular catabolic process

5 of 74

1.9

2.4

5.77e-06

GO:0071230

Cellular response to amino acid stimulus

3 of 8

2.64

2.27

6.39e-05

GO:0071038

Nuclear polyadenylation-dependent tRNA catabolic process

3 of 12

2.47

2.16

8.80e-05

GO:0071035

Nuclear polyadenylation-dependent rRNA catabolic process

3 of 12

2.47

2.16

8.80e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0038201

TOR complex

4 of 7

2.82

3.84

7.43e-08

GO:0031932

TORC2 complex

3 of 6

2.77

2.71

1.01e-05

GO:0000176

Nuclear exosome (RNase complex)

3 of 12

2.47

2.33

4.11e-05

GO:1990131

Gtr1-Gtr2 GTPase complex

2 of 2

3.07

1.88

0.00039

GO:0031931

TORC1 complex

2 of 3

2.89

1.78

0.00058

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4006

Mixed, incl. TOR complex, and Gtr1/RagA G protein

7 of 12

2.83

7.61

2.52e-15

CL:4008

Mixed, incl. Gtr1/RagA G protein, and snRNA catabolic process

4 of 6

2.89

4.31

1.06e-08

CL:4020

TORC2 complex

3 of 5

2.85

2.93

4.14e-06

CL:6567

Nuclear polyadenylation-dependent ncRNA catabolic process

2 of 11

2.33

1.15

0.0075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

3 of 99

1.55

0.92

0.0113

map04136

Autophagy - other

2 of 28

1.92

0.88

0.0211

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389357

CD28 dependent PI3K/Akt signaling

3 of 6

2.77

2.49

2.66e-05

MAP-6806003

Regulation of TP53 Expression and Degradation

3 of 9

2.59

2.46

2.66e-05

MAP-6804757

Regulation of TP53 Degradation

3 of 9

2.59

2.46

2.66e-05

MAP-5218920

VEGFR2 mediated vascular permeability

3 of 11

2.5

2.44

2.66e-05

MAP-389356

CD28 co-stimulation

3 of 11

2.5

2.44

2.66e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0038201

TOR complex

4 of 8

2.77

3.69

1.36e-07

GOCC:0000178

Exosome (RNase complex)

3 of 13

2.43

2.17

8.24e-05

GOCC:0031931

TORC1 complex

2 of 4

2.77

1.5

0.0019

GOCC:0070209

ASTRA complex

2 of 5

2.67

1.46

0.0022

GOCC:0031932

TORC2 complex

2 of 6

2.59

1.42

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006762

Gtr1/RagA G protein

2 of 2

3.07

1.09

0.0109

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