ANU56141.1 protein (Hungateiclostridiaceae bacterium KB18)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

ANU56141.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)

Predicted Functional Partners:

ANU55848.1

0.851

ANU56140.1

0.833

ANU55844.1

0.522

ANU52822.1

0.496

ANU53673.1

0.477

ANU55847.2

0.415

ANU55846.1

0.401

Your Current Organism:

Hungateiclostridiaceae bacterium KB18

NCBI taxonomy Id: 1834198
Other names: H. bacterium KB18, Ruminiclostridium sp. KB18

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANU52822.1	ANU55844.1	A4V00_01610	A4V00_18535	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
ANU52822.1	ANU56140.1	A4V00_01610	A4V00_18555	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.835
ANU52822.1	ANU56141.1	A4V00_01610	A4V00_18565	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.496
ANU53673.1	ANU55844.1	A4V00_06340	A4V00_18535	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.521
ANU53673.1	ANU56140.1	A4V00_06340	A4V00_18555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.513
ANU53673.1	ANU56141.1	A4V00_06340	A4V00_18565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.477
ANU55844.1	ANU52822.1	A4V00_18535	A4V00_01610	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.829
ANU55844.1	ANU53673.1	A4V00_18535	A4V00_06340	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.521
ANU55844.1	ANU55846.1	A4V00_18535	A4V00_18545	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ANU55844.1	ANU55847.2	A4V00_18535	A4V00_18550	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.482
ANU55844.1	ANU55848.1	A4V00_18535	A4V00_18560	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.920
ANU55844.1	ANU56140.1	A4V00_18535	A4V00_18555	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.492
ANU55844.1	ANU56141.1	A4V00_18535	A4V00_18565	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.522
ANU55846.1	ANU55844.1	A4V00_18545	A4V00_18535	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
ANU55846.1	ANU55847.2	A4V00_18545	A4V00_18550	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
ANU55846.1	ANU55848.1	A4V00_18545	A4V00_18560	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Anaerobic sulfatase maturase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
ANU55846.1	ANU56140.1	A4V00_18545	A4V00_18555	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
ANU55846.1	ANU56141.1	A4V00_18545	A4V00_18565	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.401
ANU55847.2	ANU55844.1	A4V00_18550	A4V00_18535	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.482
ANU55847.2	ANU55846.1	A4V00_18550	A4V00_18545	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.872

expected number of edges:

14

PPI enrichment p-value:

0.000424

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000271

Polysaccharide biosynthetic process

6 of 59

1.59

2.18

1.58e-06

GO:0009252

Peptidoglycan biosynthetic process

4 of 28

1.74

1.85

7.57e-05

GO:0008360

Regulation of cell shape

4 of 28

1.74

1.85

7.57e-05

GO:0071555

Cell wall organization

4 of 31

1.7

1.81

7.57e-05

GO:0033692

Cellular polysaccharide biosynthetic process

5 of 55

1.54

1.78

2.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

3 of 14

1.92

1.11

0.0068

GO:0016757

Glycosyltransferase activity

4 of 70

1.34

0.86

0.0101

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3065

Mixed, incl. Nucleotide-diphospho-sugar transferases, and O-Antigen nucleotide sugar biosynthesis

7 of 44

1.79

3.17

6.83e-09

CL:2321

Mur ligase, C-terminal, and Glycosyl transferase family 4

4 of 6

2.41

3.16

7.73e-07

CL:3067

Mixed, incl. Nucleotide-diphospho-sugar transferases, and Streptomycin biosynthesis

4 of 31

1.7

1.77

0.00010

CL:3071

Mixed, incl. Polyketide sugar unit biosynthesis, and Glycosyltransferase like family 2

3 of 12

1.98

1.72

0.00037

CL:3073

Glycosyltransferase like family 2, and ABC-2 type transporter

2 of 5

2.19

1.17

0.0065

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

4 of 28

1.74

1.79

0.00011

map01502

Vancomycin resistance

2 of 9

1.93

0.96

0.0146

map01100

Metabolic pathways

10 of 1471

0.42

0.31

0.0129

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0573

Peptidoglycan synthesis

4 of 18

1.93

2.09

4.22e-05

KW-0961

Cell wall biogenesis/degradation

4 of 21

1.87

2.04

4.22e-05

KW-0132

Cell division

4 of 38

1.61

1.62

0.00016

KW-0131

Cell cycle

4 of 38

1.61

1.62

0.00016

KW-0436

Ligase

3 of 84

1.14

0.58

0.0422

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 4

2.46

1.9

0.00029

PF08245

Mur ligase middle domain

3 of 5

2.36

1.88

0.00029

PF01225

Mur ligase family, catalytic domain

2 of 3

2.41

1.03

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004101

Mur ligase, C-terminal

3 of 4

2.46

1.69

0.00074

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.36

1.67

0.00074

IPR036565

Mur-like, catalytic domain superfamily

3 of 5

2.36

1.67

0.00074

IPR013221

Mur ligase, central

3 of 5

2.36

1.67

0.00074

IPR001173

Glycosyltransferase 2-like

3 of 9

2.11

1.57

0.00092

(more ...)

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