STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDE83_000831N-glycosylase dna lyase. (367 aa)    
Predicted Functional Partners:
DDE83_003065
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
    
  0.757
DDE83_006754
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
    
 
 0.708
DDE83_002348
Sister chromatid cohesion protein eso1.
   
 
 0.669
DDE83_001186
Sister chromatid cohesion protein eso1.
   
 
 0.669
NTH1
Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
   
 
 0.648
DDE83_006504
DNA binding methylated-DNA--cysteine S-methyltransferase.
  
 
 0.617
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 
 0.612
DDE83_000745
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
    
 
 0.597
DDE83_006446
Dna-(Apurinic or apyrimidinic site) lyase.
   
 
 0.587
DDE83_006411
DNA polymerase.
    
 
 0.580
Your Current Organism:
Stemphylium lycopersici
NCBI taxonomy Id: 183478
Other names: CBS 116585 [[Stemphylium xanthosomatis]], CBS 120325 [[Stemphylium sophorae]], CBS 120326 [[Stemphylium oblongum]], CBS 122639, CBS 122803 [[Stemphylium pyrina]], CBS 124980 [[Stemphylium pruni]], CBS 124981 [[Stemphylium plantaginis]], IMI 98083 [[Stemphylium xanthosomatis]], S. lycopersici, Stemphylium oblongum, Stemphylium oblongum Yong Wang bis & X.G. Zhang, 2009, Stemphylium plantaginis, Stemphylium plantaginis Yong Wang bis & X.G. Zhang, 2006, Stemphylium pruni, Stemphylium pruni Yong Wang bis & X.G. Zhang, 2006, Stemphylium pyrina, Stemphylium pyrina Yong Wang bis & X.G. Zhang, 2009, Stemphylium sophorae, Stemphylium sophorae Yong Wang bis & X.G. Zhang, 2009, Stemphylium xanthosomae, Stemphylium xanthosomatis
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