KIH96696.1 protein (Streptomonospora alba) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

KIH96696.1

RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)

Predicted Functional Partners:

mshC

0.789

cysS

0.789

KII00187.1

0.759

KIH99127.1

0.759

KIH98909.1

0.757

KII00027.1

0.754

KII00026.1

0.753

KIH97370.1

0.746

KIH98222.1

0.744

KIH97651.1

0.740

Your Current Organism:

Streptomonospora alba

NCBI taxonomy Id: 183763
Other names: CCTCC AA 001013, DSM 44588, JCM 12680, S. alba, Streptimonospora albus, Streptomonospora alba Li et al. 2003, Streptomonospora albus, YIM 90003

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIH96696.1	KIH97370.1	LP52_23645	LP52_19055	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
KIH96696.1	KIH97651.1	LP52_23645	LP52_18060	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
KIH96696.1	KIH98222.1	LP52_23645	LP52_14670	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.744
KIH96696.1	KIH98909.1	LP52_23645	LP52_10815	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.757
KIH96696.1	KIH99127.1	LP52_23645	LP52_09650	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.759
KIH96696.1	KII00026.1	LP52_23645	LP52_03515	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.753
KIH96696.1	KII00027.1	LP52_23645	LP52_03520	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.754
KIH96696.1	KII00187.1	LP52_23645	LP52_02305	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sporulation protein SsgA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.759
KIH96696.1	cysS	LP52_23645	LP52_23700	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	cysteinyl-tRNA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.789
KIH96696.1	mshC	LP52_23645	LP52_22535	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.	0.789
KIH97370.1	KIH96696.1	LP52_19055	LP52_23645	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
KIH97370.1	KIH97651.1	LP52_19055	LP52_18060	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
KIH97370.1	KIH98222.1	LP52_19055	LP52_14670	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
KIH97370.1	KIH98909.1	LP52_19055	LP52_10815	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
KIH97370.1	KIH99127.1	LP52_19055	LP52_09650	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
KIH97370.1	KII00027.1	LP52_19055	LP52_03520	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
KIH97370.1	KII00187.1	LP52_19055	LP52_02305	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sporulation protein SsgA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.563
KIH97651.1	KIH96696.1	LP52_18060	LP52_23645	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.740
KIH97651.1	KIH97370.1	LP52_18060	LP52_19055	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775
KIH97651.1	KIH98909.1	LP52_18060	LP52_10815	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.775

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.913

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

6 of 18

2.6

5.4

3.12e-11

GO:0015990

Electron transport coupled proton transport

2 of 2

3.08

1.58

0.0014

GO:0022607

Cellular component assembly

7 of 557

1.18

1.24

5.29e-05

GO:1902600

Proton transmembrane transport

3 of 120

1.48

0.74

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 25

2.28

2.57

1.02e-05

GO:0015399

Primary active transmembrane transporter activity

5 of 146

1.61

1.91

1.91e-05

GO:0048038

Quinone binding

2 of 10

2.38

1.2

0.0062

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

5 of 59

2.01

2.94

4.40e-07

GO:0005747

Mitochondrial respiratory chain complex I

4 of 25

2.28

2.93

1.74e-06

GO:0098798

Mitochondrial protein-containing complex

5 of 195

1.49

1.72

2.52e-05

GO:0005743

Mitochondrial inner membrane

5 of 272

1.34

1.39

0.00011

GO:0005739

Mitochondrion

10 of 1039

1.06

1.31

8.48e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10257

Respirasome, and NAD(P)H-binding

9 of 91

2.07

5.68

6.58e-15

CL:10427

NADH dehydrogenase complex assembly

4 of 6

2.9

4.4

7.21e-09

CL:10281

Complex I biogenesis

5 of 29

2.31

4.08

5.37e-09

CL:10284

Complex I biogenesis

4 of 24

2.3

3.18

5.29e-07

CL:10287

NADH dehydrogenase complex

3 of 17

2.32

2.27

4.46e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 148

1.69

2.6

1.56e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

8 of 34

2.45

7.16

8.18e-16

MAP-611105

Respiratory electron transport

8 of 68

2.15

5.63

6.49e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 82

2.07

5.24

1.77e-13

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 173

1.74

3.59

4.11e-11

MAP-1430728

Metabolism

9 of 2359

0.66

0.52

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 810

1.07

1.12

3.00e-05

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3298

0.56

0.42

0.0042

GOCC:0005737

Cytoplasm

10 of 3536

0.53

0.4

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 41

1.94

1.44

0.0014

KW-0004

4Fe-4S

2 of 12

2.3

1.16

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.32

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006138

NADH-ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.08

0.0115

IPR006137

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

2 of 2

3.08

1.08

0.0115

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