APX71979.1 protein (Lactobacillus allii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

APX71979.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)

Predicted Functional Partners:

APX71981.1

0.941

APX71982.1

0.895

APX71977.1

0.813

APX71978.1

0.784

APX71980.1

0.754

APX71975.1

0.750

APX71976.1

0.625

APX71974.1

0.589

APX73336.1

0.576

APX71983.1

0.527

Your Current Organism:

Lactobacillus allii

NCBI taxonomy Id: 1847728
Other names: JCM 31938, KCTC 21077, L. allii, Lactobacillus allii Jung et al. 2017, Lactobacillus sp. WiKim39, strain WiKim39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APX71974.1	APX71975.1	BTM29_05120	BTM29_05125	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.843
APX71974.1	APX71976.1	BTM29_05120	BTM29_05130	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.698
APX71974.1	APX71977.1	BTM29_05120	BTM29_05135	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.586
APX71974.1	APX71978.1	BTM29_05120	BTM29_05140	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.546
APX71974.1	APX71979.1	BTM29_05120	BTM29_05145	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.589
APX71974.1	APX71980.1	BTM29_05120	BTM29_05150	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.488
APX71974.1	APX71981.1	BTM29_05120	BTM29_05155	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	UDP-galactopyranose mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
APX71974.1	APX71982.1	BTM29_05120	BTM29_05160	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.568
APX71974.1	APX73336.1	BTM29_05120	BTM29_05115	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chain-length determining protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987
APX71975.1	APX71974.1	BTM29_05125	BTM29_05120	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.843
APX71975.1	APX71976.1	BTM29_05125	BTM29_05130	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.837
APX71975.1	APX71977.1	BTM29_05125	BTM29_05135	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.749
APX71975.1	APX71978.1	BTM29_05125	BTM29_05140	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.716
APX71975.1	APX71979.1	BTM29_05125	BTM29_05145	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.750
APX71975.1	APX71980.1	BTM29_05125	BTM29_05150	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.631
APX71975.1	APX71981.1	BTM29_05125	BTM29_05155	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	UDP-galactopyranose mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.739
APX71975.1	APX71982.1	BTM29_05125	BTM29_05160	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.816
APX71975.1	APX73336.1	BTM29_05125	BTM29_05115	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chain-length determining protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.804
APX71976.1	APX71974.1	BTM29_05130	BTM29_05120	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.698
APX71976.1	APX71975.1	BTM29_05130	BTM29_05125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.837

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Network Stats

number of nodes:

6

number of edges:

6

average node degree:

2

avg. local clustering coefficient:

0.85

expected number of edges:

5

PPI enrichment p-value:

0.387

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

7 of 14

2.21

4.8

3.68e-11

GO:0006091

Generation of precursor metabolites and energy

9 of 117

1.39

2.25

1.97e-09

GO:0044238

Primary metabolic process

10 of 1191

0.43

0.3

0.0287

GO:0044237

Cellular metabolic process

11 of 1480

0.38

0.29

0.0162

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000104

Succinate dehydrogenase activity

4 of 4

2.51

2.95

2.61e-06

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.51

1.03

0.0130

GO:0004775

succinate-CoA ligase (ADP-forming) activity

2 of 2

2.51

1.03

0.0130

GO:0016417

S-acyltransferase activity

2 of 5

2.11

0.94

0.0170

GO:0043169

Cation binding

7 of 452

0.7

0.46

0.0151

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

4 of 26

1.69

1.68

0.00017

GO:0045239

Tricarboxylic acid cycle enzyme complex

2 of 3

2.33

1.31

0.0037

GO:1902494

Catalytic complex

5 of 88

1.26

1.21

0.00029

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28827812

(2017) Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of alpha-ketoglutarate.

2 of 7

1.96

0.79

0.0316

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1043

Succinate dehydrogenase activity, and succinate-CoA ligase activity

6 of 6

2.51

5.25

3.91e-11

CL:997

Citrate cycle (TCA cycle), and Malic enzyme activity

9 of 29

2.0

5.22

3.09e-14

CL:999

acetyl-CoA metabolic process, and Dihydrolipoyl dehydrogenase activity

3 of 13

1.87

1.43

0.0013

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pga00020

Citrate cycle (TCA cycle)

9 of 25

2.06

5.84

1.34e-15

pga01200

Carbon metabolism

11 of 117

1.48

3.12

5.07e-15

pga01120

Microbial metabolism in diverse environments

11 of 235

1.18

1.82

5.53e-12

pga00650

Butanoate metabolism

4 of 37

1.54

1.63

9.01e-05

pga00190

Oxidative phosphorylation

4 of 45

1.45

1.47

0.00016

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

5 of 7

2.36

3.84

2.39e-08

GOCC:0045273

Respiratory chain complex II

3 of 3

2.51

2.23

6.76e-05

GOCC:0045252

Oxoglutarate dehydrogenase complex

3 of 4

2.38

2.19

7.11e-05

GOCC:1990204

Oxidoreductase complex

5 of 59

1.43

1.54

7.11e-05

GOCC:0045283

Fumarate reductase complex

2 of 2

2.51

1.49

0.0018

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

4 of 9

2.15

2.55

7.66e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01127

Succinate dehydrogenase/Fumarate reductase transmembrane subunit

2 of 2

2.51

0.86

0.0272

PF00549

CoA-ligase

2 of 2

2.51

0.86

0.0272

PF02817

e3 binding domain

2 of 3

2.33

0.85

0.0272

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 3

2.33

0.85

0.0272

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