STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHK32764.1Serine protease, S1-C subfamily, contains C-terminal PDZ domain. (818 aa)    
Predicted Functional Partners:
arc
Proteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
    
 0.916
SHL49513.1
Putative serine protease PepD.
  
  
 
0.916
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.815
SHK21183.1
Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN metalloenzyme (JAMM) motif.
   
  0.739
SHK32739.1
Molybdenum cofactor synthesis domain-containing protein.
  
    0.674
SHK67177.1
Colicin V production protein.
  
  
 0.665
prcA
Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
    
 0.660
prcB
Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
    
 0.660
SHK32804.1
Two-component system, OmpR family, response regulator MprA.
 
    0.660
SHK49834.1
Catalase; Belongs to the catalase family.
   
 0.656
Your Current Organism:
Pseudonocardia thermophila
NCBI taxonomy Id: 1848
Other names: ATCC 19285, DSM 43832, IFO 15559, JCM 3095, NBRC 15559, VKM Ac-896
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.