STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHK43018.1Hypothetical protein. (197 aa)    
Predicted Functional Partners:
SHK42978.1
Hypothetical protein.
       0.666
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.666
SHL18897.1
Heparin binding hemagglutinin HbhA.
  
     0.631
SHK42998.1
Hypothetical protein.
       0.628
SHK82141.1
Hypothetical protein.
  
     0.554
SHK20163.1
PH domain-containing protein.
  
     0.534
SHL51082.1
Protein of unknown function.
  
     0.534
SHK91089.1
TIGR02569 family protein.
  
     0.526
SHK35767.1
Hypothetical protein.
  
     0.523
SHK85920.1
Protein of unknown function.
  
     0.523
Your Current Organism:
Pseudonocardia thermophila
NCBI taxonomy Id: 1848
Other names: ATCC 19285, DSM 43832, IFO 15559, JCM 3095, NBRC 15559, VKM Ac-896
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.