STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (198 aa)    
Predicted Functional Partners:
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.929
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.913
KXB81784.1
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.830
KXB81518.1
KEGG: lmj:LMOG_02548 1.5e-285 anaerobic ribonucleoside-triphosphate reductase; K00527 ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 7.50.
    
  0.743
KXB80921.1
KEGG: mcu:HMPREF0573_10832 5.7e-261 nrdD; anaerobic ribonucleoside triphosphate reductase K00527; Psort location: Cytoplasmic, score: 7.50.
    
  0.743
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.664
KXB80653.1
Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
 0.524
KXB80573.1
Hydrolase, NUDIX family; KEGG: jde:Jden_1133 3.7e-44 NUDIX hydrolase; K01515 ADP-ribose pyrophosphatase; Psort location: CytoplasmicMembrane, score: 8.16.
   
  0.513
KXB81785.1
Transporter, major facilitator family protein; KEGG: ase:ACPL_1277 7.2e-72 EmrB/QacA subfamily drug resistance transporter; Psort location: CytoplasmicMembrane, score: 10.00.
       0.464
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.416
Your Current Organism:
Varibaculum cambriense
NCBI taxonomy Id: 184870
Other names: CCUG 44998, CIP 107344, DSM 15806, V. cambriense, Varibaculum cambriense corrig. Hall et al. 2003, Varibaculum cambriensis, strain R12359
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