STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pdxSPyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (304 aa)    
Predicted Functional Partners:
pdxT
Pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
 0.999
KXB80195.1
Transketolase; KEGG: cmi:CMM_1734 1.1e-230 tktA; transketolase K00615; Psort location: Cytoplasmic, score: 7.50; Belongs to the transketolase family.
   
 
  0.917
KXB81884.1
KEGG: cfl:Cfla_0881 3.4e-128 ribose-phosphate pyrophosphokinase K00948; Psort location: Cytoplasmic, score: 9.97.
   
 
  0.914
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
     
 0.913
KXB79697.1
Transaldolase; KEGG: pfr:PFREUD_19040 1.6e-130 tal2; transaldolase K00616; Psort location: Cytoplasmic, score: 7.50.
    
  0.901
KXB82042.1
Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: cdb:CDBH8_1287 2.8e-140 gapA; glyceraldehyde-3-phosphate dehydrogenase K00134; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.808
lipB
Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
      
 0.775
nnrD
Putative YjeF domain protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family.
  
 
  0.559
KXB80020.1
DNA-binding regulatory protein, YebC/PmpR family; KEGG: rdn:HMPREF0733_12022 9.2e-71 glucose-1-phosphate adenylyltransferase; Psort location: Cytoplasmic, score: 7.50.
     
 0.544
KXB81757.1
Kinase, PfkB family; KEGG: mcu:HMPREF0573_11505 3.2e-132 putative fructokinase; K00847 fructokinase; Psort location: Cytoplasmic, score: 7.50.
     
 0.523
Your Current Organism:
Varibaculum cambriense
NCBI taxonomy Id: 184870
Other names: CCUG 44998, CIP 107344, DSM 15806, V. cambriense, Varibaculum cambriense corrig. Hall et al. 2003, Varibaculum cambriensis, strain R12359
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