STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KXB80659.1KEGG: cuc:CULC809_01915 4.3e-50 gpt; purine phosphoribosyltransferase K07101; Psort location: Cytoplasmic, score: 7.50. (176 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.833
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
  
 
  0.792
KXB80658.1
IMP dehydrogenase family protein; KEGG: scy:SCATT_53580 2.1e-167 inosine 5-monophosphate dehydrogenase; K00088 IMP dehydrogenase; Psort location: Cytoplasmic, score: 7.50.
  
 
 0.682
KXB80660.1
Hypothetical protein; Psort location: Cytoplasmic, score: 7.50.
       0.658
apt
Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 0.551
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.539
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
  0.503
KXB80197.1
Xanthine permease; KEGG: apb:SAR116_1372 3.8e-58 xanthine/uracil permease K03458; Psort location: CytoplasmicMembrane, score: 10.00.
 
     0.491
purH
KEGG: bfa:Bfae_24100 2.1e-176 IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase K00602; Psort location: Cytoplasmic, score: 7.50.
    
 0.484
KXB80661.1
Kinase domain protein; KEGG: fal:FRAAL5298 1.0e-46 Serine/threonine protein kinase PkaA K08884; Psort location: CytoplasmicMembrane, score: 8.78.
       0.469
Your Current Organism:
Varibaculum cambriense
NCBI taxonomy Id: 184870
Other names: CCUG 44998, CIP 107344, DSM 15806, V. cambriense, Varibaculum cambriense corrig. Hall et al. 2003, Varibaculum cambriensis, strain R12359
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