STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa)    
Predicted Functional Partners:
KXB81026.1
Aldehyde dehydrogenase family protein; KEGG: mcu:HMPREF0573_11678 0. L-proline dehydrogenase / delta-1-pyrroline-5-carboxylate dehydrogenase K13821; Psort location: Cytoplasmic, score: 9.97; Belongs to the aldehyde dehydrogenase family.
   
 0.965
KXB79735.1
Pyridoxal phosphate enzyme, YggS family; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
 0.855
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.787
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
     
 0.782
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
     
 0.777
KXB81158.1
KEGG: ssm:Spirs_0789 3.5e-110 aldehyde dehydrogenase; K00128 aldehyde dehydrogenase (NAD+); Psort location: Cytoplasmic, score: 9.97.
   
 
 0.760
KXB81181.1
KEGG: pak:HMPREF0675_3499 1.1e-202 mmsA; methylmalonate-semialdehyde dehydrogenase (acylating) K00140; Psort location: Cytoplasmic, score: 9.97.
   
 
 0.760
KXB80683.1
Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
  0.736
KXB80931.1
KEGG: bcv:Bcav_3976 9.7e-163 adenylosuccinate lyase K01756; Psort location: Cytoplasmic, score: 7.50.
     
 0.730
KXB80704.1
Hydrolase, alpha/beta domain protein; KEGG: bde:BDP_1811 3.1e-24 hydrolase; Psort location: Cytoplasmic, score: 7.50.
    
  0.729
Your Current Organism:
Varibaculum cambriense
NCBI taxonomy Id: 184870
Other names: CCUG 44998, CIP 107344, DSM 15806, V. cambriense, Varibaculum cambriense corrig. Hall et al. 2003, Varibaculum cambriensis, strain R12359
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.