CEN45540.1 protein (Capnocytophaga canis) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CEN45540.1

Bla. (463 aa)

Predicted Functional Partners:

CEN48954.1

0.972

susB

0.865

GLC

0.851

mdxK

0.831

CEN45480.1

0.822

susA

0.805

CEN48541.1

0.727

CEN45196.1

0.701

CEN46192.1

0.642

CEN44376.1

0.602

Your Current Organism:

Capnocytophaga canis

NCBI taxonomy Id: 1848903
Other names: C. canis, Capnocytophaga canis Renzi et al. 2016, Capnocytophaga sp. HP20001, Capnocytophaga sp. HP33001, Capnocytophaga sp. HP40001, DSM 101831, LMG 29146, LMG:29146, strain CcD38

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEN44376.1	CEN45540.1	CCAND38_180012	CCAND38_240075	Hypothetical protein; No homology to any previously reported sequences.	Bla.	0.602
CEN44376.1	GLC	CCAND38_180012	CCAND38_240042	Hypothetical protein; No homology to any previously reported sequences.	1,4-alpha-glucan-branching enzyme.	0.602
CEN45196.1	CEN45540.1	CCAND38_230017	CCAND38_240075	Hypothetical protein; No homology to any previously reported sequences.	Bla.	0.701
CEN45196.1	CEN46192.1	CCAND38_230017	CCAND38_320006	Hypothetical protein; No homology to any previously reported sequences.	Glycosyl hydrolase, family 31; Belongs to the glycosyl hydrolase 31 family.	0.644
CEN45196.1	GLC	CCAND38_230017	CCAND38_240042	Hypothetical protein; No homology to any previously reported sequences.	1,4-alpha-glucan-branching enzyme.	0.701
CEN45480.1	CEN45540.1	CCAND38_240052	CCAND38_240075	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Bla.	0.822
CEN45480.1	CEN46192.1	CCAND38_240052	CCAND38_320006	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Glycosyl hydrolase, family 31; Belongs to the glycosyl hydrolase 31 family.	0.818
CEN45480.1	CEN48541.1	CCAND38_240052	CCAND38_600014	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Starch (bacterial glycogen) synthase.	0.409
CEN45480.1	CEN48954.1	CCAND38_240052	CCAND38_710005	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Glycogen phosphorylase.	0.944
CEN45480.1	GLC	CCAND38_240052	CCAND38_240042	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	1,4-alpha-glucan-branching enzyme.	0.949
CEN45480.1	susA	CCAND38_240052	CCAND38_760004	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Neopullulanase SusA; Belongs to the glycosyl hydrolase 13 family.	0.426
CEN45540.1	CEN44376.1	CCAND38_240075	CCAND38_180012	Bla.	Hypothetical protein; No homology to any previously reported sequences.	0.602
CEN45540.1	CEN45196.1	CCAND38_240075	CCAND38_230017	Bla.	Hypothetical protein; No homology to any previously reported sequences.	0.701
CEN45540.1	CEN45480.1	CCAND38_240075	CCAND38_240052	Bla.	Putative alpha-amylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.822
CEN45540.1	CEN46192.1	CCAND38_240075	CCAND38_320006	Bla.	Glycosyl hydrolase, family 31; Belongs to the glycosyl hydrolase 31 family.	0.642
CEN45540.1	CEN48541.1	CCAND38_240075	CCAND38_600014	Bla.	Starch (bacterial glycogen) synthase.	0.727
CEN45540.1	CEN48954.1	CCAND38_240075	CCAND38_710005	Bla.	Glycogen phosphorylase.	0.972
CEN45540.1	GLC	CCAND38_240075	CCAND38_240042	Bla.	1,4-alpha-glucan-branching enzyme.	0.851
CEN45540.1	mdxK	CCAND38_240075	CCAND38_290004	Bla.	Maltose phosphorylase.	0.831
CEN45540.1	susA	CCAND38_240075	CCAND38_760004	Bla.	Neopullulanase SusA; Belongs to the glycosyl hydrolase 13 family.	0.805

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009156

Ribonucleoside monophosphate biosynthetic process

7 of 49

1.92

3.85

3.20e-10

GO:0072522

Purine-containing compound biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009260

Ribonucleotide biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

6 of 38

1.96

3.61

3.94e-09

GO:0046112

Nucleobase biosynthetic process

4 of 10

2.37

3.38

2.42e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004044

Amidophosphoribosyltransferase activity

2 of 2

2.76

1.18

0.0073

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

2 of 10

2.06

0.73

0.0441

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 9

2.11

0.73

0.0441

GO:0046872

Metal ion binding

6 of 627

0.74

0.42

0.0441

GO:0003824

Catalytic activity

11 of 2064

0.49

0.38

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5740

Purine ribonucleoside monophosphate biosynthesis

5 of 11

2.42

4.14

6.73e-09

CL:5735

Nucleotide biosynthesis

6 of 30

2.06

3.77

4.39e-09

CL:5744

Purine nucleobase metabolic process, and Class II PurE

4 of 5

2.67

3.77

7.99e-08

CL:5573

Mixed, incl. Metabolism of nucleotides, and Cellular modified amino acid metabolic process

10 of 149

1.59

3.35

6.95e-13

CL:5581

Nucleoside monophosphate phosphorylation, and Drug ADME

4 of 15

2.19

2.85

1.90e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

8 of 97

1.68

3.33

7.55e-11

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.97

2.52

4.31e-06

map00670

One carbon pool by folate

2 of 18

1.81

0.94

0.0147

map01100

Metabolic pathways

10 of 959

0.78

0.77

3.44e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-15869

Metabolism of nucleotides

9 of 65

1.9

4.75

8.61e-14

MAP-8956320

Nucleotide biosynthesis

7 of 38

2.03

4.34

5.98e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

6 of 36

1.99

3.59

5.86e-09

MAP-1430728

Metabolism

10 of 631

0.96

1.11

1.70e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1726

0.53

0.38

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 6

2.59

3.56

1.82e-07

KW-0460

Magnesium

4 of 45

1.71

1.8

8.87e-05

KW-0630

Potassium

2 of 6

2.29

1.25

0.0046

KW-0963

Cytoplasm

3 of 105

1.22

0.68

0.0257

KW-0560

Oxidoreductase

2 of 32

1.56

0.67

0.0448

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13522

Glutamine amidotransferase domain

2 of 2

2.76

1.04

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017932

Glutamine amidotransferase type 2 domain

2 of 2

2.76

0.77

0.0400

IPR005854

Amidophosphoribosyltransferase

2 of 2

2.76

0.77

0.0400

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